U2 small nuclear ribonucleoprotein A' (SNRPA1) is a 255-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P09661.
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The mean pLDDT of this model is 87.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128)
Identified in the spliceosome B complex (PubMed:28781166, PubMed:32494006, PubMed:36797247). Identified in the spliceosome C complex (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:32494006, PubMed:36797247). Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2 (PubMed:9531537). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1A9N | X-ray | 2.38 Å | A/C=1-176 |
| 7EVO | EM | 2.5 Å | F=1-255 |
| 8H6L | EM | 2.6 Å | 2B=1-255 |
| 8H6K | EM | 2.7 Å | 2B=1-255 |
| 8HK1 | EM | 2.7 Å | F=1-255 |
| 8C6J | EM | 2.8 Å | W=1-255 |
| 6ID1 | EM | 2.86 Å | o=1-255 |
| 6ID0 | EM | 2.9 Å | o=1-255 |
| 6ICZ | EM | 3.0 Å | o=1-255 |
| 7VPX | EM | 3.0 Å | F=1-255 |
| 8I0R | EM | 3.0 Å | o=1-255 |
| 8I0T | EM | 3.0 Å | o=1-255 |
| 8I0V | EM | 3.0 Å | o=1-255 |
| 8H6E | EM | 3.2 Å | 2B=1-255 |
| 8H6J | EM | 3.25 Å | 2B=1-255 |
| 6QX9 | EM | 3.28 Å | 2A=1-255 |
| 6QDV | EM | 3.3 Å | W=2-163 |
| 8I0U | EM | 3.3 Å | o=1-255 |
| 9FMD | EM | 3.3 Å | o=1-255 |
| 8I0P | EM | 3.4 Å | o=1-255 |
Showing 20 of 49 experimental structures (best resolution first).
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