Secreted effector protein EspF(U) (espF(U)) is a 337-residue protein from Escherichia coli O157:H7. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0DJ89.
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The mean pLDDT of this model is 56.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 28% |
| Below 50 | Very low: often disordered regions | 43% |
What pLDDT means and how to read it
Required for efficient pedestal formation in host epithelial cells during infection. Acts as an intermediate between Tir (via host BAIAP2) and host WASL/N-WASP. Directly binds and activates WASL/N-WASP, which stimulates actin polymerization and leads to the formation of actin pedestals at the sites of bacterial adhesion
Interacts with host BAIAP2 and host WASL/N-WASP (By similarity). Can also interact with host proteins BAIAP2L1 and WAS/WASP. Identified in a complex with host proteins BAIAP2L1 and WASL
Secreted, Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
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