Internalin A (inlA) is a 800-residue protein from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0DJM0.
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The mean pLDDT of this model is 87.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 80% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
Mediates the entry of L.monocytogenes into host intestinal epithelial cells; transformation with inlA alone allows L.innocua (a non-invasive species) to be taken up by host cells (PubMed:10406800, PubMed:1905979, PubMed:8601315). Binds to human receptor cadherin-1 (E-cadherin, CDH1); the chicken homolog of cadherin-1 but not cadherin-2 function as receptors (PubMed:8601315). Mouse cadherin-1 is not a receptor, however mutating a single surface-exposed residue (Glu-172 to Pro in mouse) allows cadherin-1 to act as a receptor for InlA (PubMed:10406800)
Interacts with host (human) cadherin-1 (CDH1) (PubMed:12526809, PubMed:17540170, PubMed:17715295). The formation of the complex between inlA and cadherin-1 is calcium-dependent (PubMed:12526809). Mutagenesis studies show it is possible to increase the affinity of InlA for CDH1 by rational engineering of InlA residues (PubMed:17715295)
Secreted, cell wall, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1O6V | X-ray | 1.5 Å | A/B=35-496 |
| 8H63 | X-ray | 1.53 Å | A=36-496 |
| 1O6T | X-ray | 1.6 Å | A=36-496 |
| 2OMZ | X-ray | 1.6 Å | A=36-495 |
| 2OMX | X-ray | 1.7 Å | A=36-496 |
| 2OMY | X-ray | 1.7 Å | A=36-495 |
| 1O6S | X-ray | 1.8 Å | A=35-496 |
| 2OMU | X-ray | 1.8 Å | A=36-496 |
| 2OMW | X-ray | 1.85 Å | A=36-496 |
| 2OMV | X-ray | 1.9 Å | A=36-495 |
| 8H62 | X-ray | 1.91 Å | A=36-496 |
| 2OMT | X-ray | 2.0 Å | A=36-496 |
| 8H64 | X-ray | 2.35 Å | A/C/E/G=36-496 |
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