Bifunctional hemolysin/adenylate cyclase (cya) is a 1706-residue protein from Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0DKX7.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 66.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Bifunctional adenylate cyclase toxin-hemolysin that plays a crucial role in host colonization (PubMed:2050107, PubMed:2542030). It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function (PubMed:2050107, PubMed:2542030)
Secreted, Host cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5CXL | X-ray | 1.45 Å | A/B=1529-1681 |
| 9P0D | X-ray | 1.5 Å | A=1529-1680 |
| 9P0C | X-ray | 1.7 Å | A/B=1529-1680 |
| 6SUS | X-ray | 1.76 Å | A=1371-1690 |
| 9P6C | X-ray | 1.99 Å | A/B=1529-1680 |
| 1YRT | X-ray | 2.1 Å | A=1-364 |
| 1ZOT | X-ray | 2.2 Å | A=7-364 |
| 2COL | X-ray | 2.2 Å | A=7-362 |
| 1YRU | X-ray | 2.5 Å | A=1-364 |
| 7RAH | X-ray | 2.6 Å | E=1015-1706 |
| 7USL | EM | 2.7 Å | C=751-1706 |
| 6YNU | X-ray | 3.12 Å | B/D=458-481 |
| 6YNS | X-ray | 3.94 Å | N/O/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/g/h/i/j/k/l=458-481 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.