Envelope small membrane protein (E) is a 75-residue protein from Severe acute respiratory syndrome coronavirus 2. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P0DTC4.
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The mean pLDDT of this model is 75.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 44% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Regulates the localization of S protein at cis-Golgi, the place of virus budding (PubMed:33229438). May act by slowing down the cell secretory pathway (PubMed:33229438). May interfere with tight-junction stability by interacting with host MPP5. This would result in disruption of epithelial barriers, thereby amplifying inflammatory processes (PubMed:32891874)
Homopentamer (PubMed:33177698). Interacts via C-terminus PDM domain with PDZ domain-containing host proteins such as PALS1/MPP5 (PubMed:32891874, PubMed:35283834), TJP1/ZO1 (PubMed:35283834), LNX2 (PubMed:35283834), PARD3 (PubMed:35283834), and AFDN/MLLT4 (PubMed:35283834). This may lead to disruption of tight junctions between epithelial cells (PubMed:32891874). Interacts with membrane protein…
Host Golgi apparatus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9HM2 | X-ray | 1.72 Å | C/D=64-75 |
| 7NTK | X-ray | 1.9 Å | C/E/G/H=68-75 |
| 7QCR | X-ray | 2.28 Å | C/D=64-75 |
| 7TV0 | X-ray | 2.6 Å | E/G=53-64 |
| 7TUQ | X-ray | 2.68 Å | C=60-68 |
| 7QCS | X-ray | 2.8 Å | C/D=64-75 |
| 7QCT | X-ray | 3.2 Å | C/D=64-75 |
| 7M4R | EM | 3.65 Å | C=58-75 |
| 7K3G | NMR | A/B/C/D/E=8-38 | |
| 8SUZ | NMR | A/B/C/D/E=8-38 | |
| 8U1T | NMR | A/B=12-37 |
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