Interleukin-8 (CXCL8) is a 99-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10145.
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The mean pLDDT of this model is 88.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, PubMed:7636208). Also plays an important role in neutrophil activation (PubMed:2145175, PubMed:9623510). Released in response to an inflammatory stimulus, exerts its effect by binding to the G protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells (PubMed:1840701, PubMed:1891716). G protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in…
Homodimer (PubMed:31235521). Dimer formation is disrupted by tick evasin-3 (PubMed:31235521). Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4XDX | X-ray | 0.95 Å | A=30-99 |
| 5D14 | X-ray | 1.0 Å | A=30-99 |
| 6N2U | X-ray | 1.25 Å | A=1-99 |
| 3IL8 | X-ray | 2.0 Å | A=28-99 |
| 1ICW | X-ray | 2.01 Å | A/B=28-99 |
| 6WZM | X-ray | 2.28 Å | E/F=28-93 |
| 1QE6 | X-ray | 2.35 Å | A/B/C/D=28-99 |
| 8XX6 | EM | 2.99 Å | D/E=21-99 |
| 8XWN | EM | 3.29 Å | D/E=21-99 |
| 6LFO | EM | 3.4 Å | D=28-92 |
| 8IC0 | EM | 3.41 Å | F=28-99 |
| 6LFM | EM | 3.5 Å | D/E=28-99 |
| 8YNF | EM | 3.65 Å | D/E/G/H=21-99 |
| 1IKL | NMR | A=28-99 | |
| 1IKM | NMR | A=28-99 | |
| 1IL8 | NMR | A/B=28-99 | |
| 1ILP | NMR | A/B=28-99 | |
| 1ILQ | NMR | A/B=28-99 | |
| 1ROD | NMR | A/B=28-80 | |
| 2IL8 | NMR | A/B=28-99 |
Showing 20 of 22 experimental structures (best resolution first).
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