Tissue factor pathway inhibitor (TFPI) is a 304-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10646.
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The mean pLDDT of this model is 73.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma
Secreted, Microsome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5NMV | X-ray | 1.65 Å | K=29-107 |
| 4DTG | X-ray | 1.8 Å | K=119-178 |
| 6BX8 | X-ray | 1.98 Å | B/D/F/H=50-107 |
| 4BQD | X-ray | 2.48 Å | A/B=29-107 |
| 1TFX | X-ray | 2.6 Å | C/D=121-178 |
| 7V1N | EM | 3.2 Å | K=1-209 |
| 9P0X | EM | 3.7 Å | K=40-107 |
| 1ADZ | NMR | A=107-182 | |
| 1IRH | NMR | A=210-270 |
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