Mast/stem cell growth factor receptor Kit (KIT) is a 976-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10721.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 78.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT…
Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and…
Cell membrane, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2VIF | X-ray | 1.45 Å | P=564-574 |
| 8PQD | X-ray | 1.5 Å | A/B=551-687, A/B=766-934 |
| 8S14 | X-ray | 1.5 Å | A=551-687, A=766-934 |
| 1T46 | X-ray | 1.6 Å | A=565-935 |
| 3G0E | X-ray | 1.6 Å | A=544-935 |
| 8PQA | X-ray | 1.65 Å | A/C=551-687, A/C=766-934 |
| 8PQ9 | X-ray | 1.7 Å | A/C=551-687, A/C=766-934 |
| 8PQC | X-ray | 1.77 Å | A/B=551-687, A/B=766-934 |
| 6MOB | X-ray | 1.8 Å | A=566-693, A=754-935 |
| 8S16 | X-ray | 1.85 Å | A/B=551-687, A/B=766-934 |
| 8S1A | X-ray | 1.85 Å | A/B=551-687, A/B=766-934 |
| 8PQB | X-ray | 1.87 Å | A=551-687, A=766-934 |
| 6ITV | X-ray | 1.88 Å | A=547-693, A=754-935 |
| 1T45 | X-ray | 1.9 Å | A=547-935 |
| 4HVS | X-ray | 1.9 Å | A=551-934 |
| 8PQF | X-ray | 1.9 Å | A/C=551-687, A/C=766-934 |
| 2IUH | X-ray | 2.0 Å | B=718-728 |
| 4U0I | X-ray | 2.0 Å | A=563-693, A=754-935 |
| 6GQM | X-ray | 2.0 Å | A/B=551-934 |
| 8PQE | X-ray | 2.0 Å | A/B=551-687, A/B=766-934 |
Showing 20 of 52 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.