Transcriptional regulator ERG (ERG) is a 479-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P11308.
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The mean pLDDT of this model is 59.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 54% |
What pLDDT means and how to read it
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4IRG | X-ray | 1.7 Å | A=306-405 |
| 4IRH | X-ray | 2.1 Å | A=280-405 |
| 5YBC | X-ray | 2.5 Å | A/C=310-401 |
| 4IRI | X-ray | 2.77 Å | A=280-405 |
| 5YBD | X-ray | 2.77 Å | A/X=310-399 |
| 6VGE | X-ray | 4.25 Å | A=306-419 |
| 6VGG | X-ray | 4.31 Å | A=306-419 |
| 1SXE | NMR | A=108-201 |
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