Cyclin-dependent kinase 4 (CDK4) is a 303-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P11802.
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The mean pLDDT of this model is 86.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary…
Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3). Interacts directly in the complex with CCND1, CCND2 or CCND3. Interacts with SEI1 and ZNF655. Forms a ternary complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity. Interacts directly with CDKN1B (phosphorylated on 'Tyr-88' and 'Tyr-89'); the interaction allows assembly of…
Cytoplasm, Nucleus, Nucleus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9CSK | X-ray | 2.25 Å | B/D=1-303 |
| 2W96 | X-ray | 2.3 Å | B=1-303 |
| 6P8E | X-ray | 2.3 Å | B=2-303 |
| 2W9Z | X-ray | 2.45 Å | B=1-303 |
| 7SJ3 | X-ray | 2.51 Å | A=2-303 |
| 2W99 | X-ray | 2.8 Å | B=1-303 |
| 6P8G | X-ray | 2.8 Å | B=2-303 |
| 2W9F | X-ray | 2.85 Å | B=1-303 |
| 6P8F | X-ray | 2.89 Å | B=2-303 |
| 3G33 | X-ray | 3.0 Å | A/C=1-303 |
| 6P8H | X-ray | 3.19 Å | B=2-303 |
| 5FWK | EM | 3.9 Å | K=1-303 |
| 5FWP | EM | 7.2 Å | K=1-303 |
| 5FWM | EM | 8.0 Å | K=1-303 |
| 5FWL | EM | 9.0 Å | K=1-303 |
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