Parathyroid hormone-related protein (PTHLH) is a 177-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P12272.
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The mean pLDDT of this model is 62.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 16% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 50% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport (PubMed:12538599, PubMed:35932760, PubMed:3616618). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed:19674967, PubMed:35932760). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Required for skeletal homeostasis (PubMed:12538599). Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs (PubMed:12538599).…
Interacts with PTH1R (via N-terminal extracellular domain)
Secreted, Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7UZO | X-ray | 1.3 Å | B=51-72 |
| 3H3G | X-ray | 1.94 Å | B=48-70 |
| 3FFD | X-ray | 2.0 Å | P=37-144 |
| 8D51 | X-ray | 2.0 Å | B=51-72 |
| 8D52 | X-ray | 2.02 Å | B=51-72 |
| 7UZP | X-ray | 2.29 Å | B/D/F=52-72 |
| 1M5N | X-ray | 2.9 Å | Q=103-130 |
| 8FLR | EM | 2.94 Å | P=37-72 |
| 7VVJ | EM | 3.2 Å | P=37-72 |
| 8HAF | EM | 3.25 Å | P=37-72 |
| 1BZG | NMR | A=37-70 |
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