Uracil-DNA glycosylase (UNG) is a 313-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13051.
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The mean pLDDT of this model is 85.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Uracil-DNA glycosylase that hydrolyzes the N-glycosidic bond between uracil and deoxyribose in single- and double-stranded DNA (ssDNA and dsDNA) to release a free uracil residue and form an abasic (apurinic/apyrimidinic; AP) site. Excises uracil residues arising as a result of misincorporation of dUMP residues by DNA polymerase during replication or due to spontaneous or enzymatic deamination of cytosine (PubMed:12958596, PubMed:15967827, PubMed:17101234, PubMed:22521144, PubMed:7671300, PubMed:8900285, PubMed:9016624, PubMed:9776759). Mediates error-free base excision repair (BER) of uracil at replication forks. According to the model, it is recruited by PCNA to S-phase replication forks…
Monomer
Mitochondrion, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3FCI | X-ray | 1.27 Å | A=94-313 |
| 2HXM | X-ray | 1.3 Å | A=94-313 |
| 3TKB | X-ray | 1.5 Å | A=94-313 |
| 1AKZ | X-ray | 1.57 Å | A=94-313 |
| 3FCK | X-ray | 1.64 Å | B=94-313 |
| 3FCL | X-ray | 1.7 Å | A/B=94-313 |
| 9LNQ | X-ray | 1.74 Å | E=94-312 |
| 9LNP | X-ray | 1.76 Å | E=94-313 |
| 1EMH | X-ray | 1.8 Å | A=91-313 |
| 6VBA | X-ray | 1.8 Å | A=94-313 |
| 3FCF | X-ray | 1.84 Å | A=94-313 |
| 1Q3F | X-ray | 1.9 Å | A=94-313 |
| 1SSP | X-ray | 1.9 Å | E=94-313 |
| 1UGH | X-ray | 1.9 Å | E=94-313 |
| 1YUO | X-ray | 1.95 Å | A=91-313 |
| 1EMJ | X-ray | 2.0 Å | A=91-313 |
| 2OYT | X-ray | 2.0 Å | A=94-313 |
| 2SSP | X-ray | 2.25 Å | E=94-313 |
| 5AYR | X-ray | 2.4 Å | A/C=94-313 |
| 2OXM | X-ray | 2.5 Å | A=94-313 |
Showing 20 of 24 experimental structures (best resolution first).
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