C-C motif chemokine 2 (CCL2) is a 99-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13500.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 86.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 61% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:10529171, PubMed:10587439, PubMed:9837883). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8195247, PubMed:8627182, PubMed:9792674). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690)
Monomer or homodimer; in equilibrium (PubMed:15033992, PubMed:8898111, PubMed:8989326, PubMed:9837883). Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans (PubMed:9792674). Interacts with TNFAIP6 (via Link domain)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7SO0 | X-ray | 1.74 Å | B=24-99 |
| 1DOK | X-ray | 1.85 Å | A/B=24-99 |
| 3IFD | X-ray | 1.9 Å | A=24-99 |
| 4R8I | X-ray | 2.05 Å | A=24-99 |
| 1DOL | X-ray | 2.4 Å | A=24-99 |
| 2NZ1 | X-ray | 2.5 Å | D/E/Y=24-99 |
| 2BDN | X-ray | 2.53 Å | A=24-99 |
| 4ZK9 | X-ray | 2.6 Å | B=24-99 |
| 1ML0 | X-ray | 2.8 Å | D=24-99 |
| 4DN4 | X-ray | 2.8 Å | M=24-99 |
| 7XA3 | EM | 2.9 Å | L=24-92 |
| 8FJ0 | X-ray | 2.91 Å | D/E/F=24-99 |
| 1DOM | NMR | A/B=24-99 | |
| 1DON | NMR | A/B=24-99 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.