cAMP-dependent protein kinase type II-alpha regulatory subunit (PRKAR2A) is a 404-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13861.
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The mean pLDDT of this model is 83.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase
The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3. Interacts with the phosphorylated form of PJA2. Interacts with MYRIP. This interaction may link PKA to components of the exocytosis machinery, thus…
Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2IZX | X-ray | 1.3 Å | A/B=4-44 |
| 5H78 | X-ray | 2.0 Å | A/B=5-49 |
| 9NXN | X-ray | 2.1 Å | C=44-103 |
| 4ZP3 | X-ray | 2.63 Å | A/B/C/D/E/F/G/H/I/J/K/L=2-44 |
| 5H77 | X-ray | 3.2 Å | A/B/C/D/E/F/G/H/I/J/K/L=5-41 |
| 5XBY | X-ray | 3.25 Å | A/B/C/D=5-44 |
| 2KYG | NMR | A/B=1-45 | |
| 8S8O | NMR | A/B=1-48 |
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