General transcription factor IIF subunit 2 (GTF2F2) is a 249-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13984.
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The mean pLDDT of this model is 82.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 57% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB
Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity). Interacts with URI1. Interacts with GTF2B (via N-terminus); this interaction is inhibited in presence of GTF2F1 (PubMed:8504927, PubMed:8662660). Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1F3U | X-ray | 1.7 Å | A/C/E/G=2-119 |
| 7NVU | EM | 2.5 Å | R=1-249 |
| 8WAV | EM | 2.72 Å | T=1-249 |
| 8WAX | EM | 2.75 Å | T=1-249 |
| 8WAZ | EM | 2.76 Å | T=1-249 |
| 8WAU | EM | 2.78 Å | T=1-249 |
| 7NVS | EM | 2.8 Å | R=1-249 |
| 8WAT | EM | 2.82 Å | T=1-249 |
| 8WAY | EM | 2.85 Å | T=1-249 |
| 7NVT | EM | 2.9 Å | R=1-249 |
| 8S52 | EM | 2.9 Å | R=1-249 |
| 8WB0 | EM | 2.94 Å | T=1-249 |
| 7ZWD | EM | 3.0 Å | R=1-249 |
| 7ZX8 | EM | 3.0 Å | R=1-249 |
| 8WAW | EM | 3.02 Å | T=1-249 |
| 8S51 | EM | 3.1 Å | R=1-249 |
| 7EGB | EM | 3.3 Å | T=1-249 |
| 7ZX7 | EM | 3.4 Å | R=1-249 |
| 8S54 | EM | 3.4 Å | R=1-249 |
| 8S55 | EM | 3.4 Å | R=1-249 |
Showing 20 of 58 experimental structures (best resolution first).
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