8S55: RNA polymerase II early elongation complex

RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state a (composite structure). Determined by electron microscopy at 3.4 Å resolution. Released 17 Apr 2024.

Method: Electron microscopy
Resolution: 3.4 Å
Organisms: Sus scrofa, unidentified adenovirus, Homo sapiens
Chains: 19
Atoms: 38,148
Mol. weight: 797.59 kDa
Ligands: MG, ZN
Released: 17 Apr 2024

Explore 8S55 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8S55 contains 209 α-helices and 263 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 76 helices, 62 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	1
β-strand	20-22	3	2
α-helix	28-34	7
α-helix	52-53	2
β-strand	86-94	9	3
α-helix	100-109	10
β-strand	110	1	4
α-helix	111	1
β-strand	117	1	4
α-helix	124-132	9
α-helix	137-150	14
β-strand	153	1	5
β-strand	187	1	5
α-helix	188-189	2
β-strand	190-194	5	6
β-strand	197-201	5	6
β-strand	214-216	3	6
α-helix	218-226	9
α-helix	230-236	7
α-helix	245-248	4
β-strand	250-255	6	3
β-strand	264	1	7
β-strand	272	1	7
α-helix	275-296	22
α-helix	301-318	18
α-helix	326-328	3
β-strand	329-330	2	8
β-strand	334-335	2	8
α-helix	339-343	5
α-helix	349	1
α-helix	350-355	6
β-strand	357-359	3	9
β-strand	362-369	8	10
β-strand	377-380	4	10
α-helix	382-387	6
β-strand	389-393	5	11
α-helix	396-398	3
α-helix	399-408	10
β-strand	416-420	5	11
β-strand	426-428	3	11
β-strand	445-449	5	11
β-strand	455-459	5	10
α-helix	466-468	3
β-strand	471-476	6	10
β-strand	482-484	3	10
α-helix	486-489	4
β-strand	500-504	5	10
α-helix	509-514	6
α-helix	515-519	5
β-strand	520	1	10
α-helix	521-524	4
β-strand	526-527	2	12
β-strand	532-533	2	12
α-helix	540-549	10
β-strand	554-555	2	13
α-helix	557-565	9
α-helix	574-577	4
β-strand	579-581	3	14
β-strand	585	1	14
β-strand	586-587	2	13
α-helix	588-595	8
β-strand	602-604	3	15
α-helix	612-615	4
β-strand	628-631	4	15
β-strand	634-637	4	15
α-helix	642-645	4
α-helix	652-659	8
α-helix	663-683	21
β-strand	686	1	16
α-helix	689-691	3
α-helix	696-722	27
α-helix	726-728	3
α-helix	733-759	27
α-helix	765-772	8
α-helix	778-785	8
β-strand	793	1	17
β-strand	796	1	17
α-helix	811	1
α-helix	833-867	35
β-strand	872-873	2	18
β-strand	879-880	2	18
β-strand	886-888	3	18
α-helix	891-893	3
β-strand	896	1	19
α-helix	898-900	3
β-strand	902-905	4	20
α-helix	913-920	8
α-helix	928-933	6
α-helix	936-943	8
α-helix	946-969	24
α-helix	971-973	3
β-strand	976-979	4	20
α-helix	983-993	11
α-helix	1001-1002	2
α-helix	1006-1019	14
α-helix	1028-1048	21
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1079	18
β-strand	1080	1	19
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1098-1101	4
α-helix	1121-1128	8
β-strand	1138-1142	5	21
β-strand	1143	1	22
α-helix	1146-1149	4
α-helix	1151-1161	11
β-strand	1164	1	23
α-helix	1166-1169	4
β-strand	1170-1177	8	24
α-helix	1190-1197	8
β-strand	1210-1216	7	24
α-helix	1218-1224	7
α-helix	1228-1239	12
β-strand	1245	1	24
β-strand	1256-1259	4	24
α-helix	1282-1295	14
β-strand	1299	1	23
β-strand	1307-1310	4	21
β-strand	1319-1322	4	25
β-strand	1328-1331	4	25
β-strand	1335-1339	5	21
α-helix	1343-1348	6
β-strand	1352	1	22
α-helix	1362-1368	7
α-helix	1371-1387	17
α-helix	1395-1406	12
α-helix	1416-1419	4
α-helix	1426-1431	6
α-helix	1437-1445	9
β-strand	1448-1449	2	2
α-helix	1454-1458	5
α-helix	1462-1464	3
β-strand	1471-1475	5	26
α-helix	1477-1481	5
β-strand	1484	1	27

Chain B: 52 helices, 87 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-60	6
β-strand	65-67	3	28
β-strand	83-88	6	28
β-strand	92-94	3	28
β-strand	97-99	3	29
β-strand	105-107	3	29
α-helix	110-116	7
β-strand	121-133	13	28
β-strand	142-153	12	28
α-helix	168-173	6
β-strand	185-187	3	30
β-strand	190-193	4	30
β-strand	197-200	4	31
α-helix	201	1
β-strand	208	1	32
β-strand	215-220	6	32
β-strand	223	1	33
β-strand	233	1	33
β-strand	236-240	5	32
β-strand	245	1	34
β-strand	247	1	34
α-helix	248-252	5
α-helix	254-255	2
β-strand	256-259	4	32
β-strand	263	1	35
β-strand	267-268	2	32
α-helix	269-275	7
α-helix	281-288	8
α-helix	295-307	13
α-helix	308-310	3
α-helix	314-323	10
β-strand	325	1	35
α-helix	332-345	14
α-helix	358-377	20
α-helix	382-384	3
α-helix	388-390	3
β-strand	391-394	4	31
α-helix	396-424	29
α-helix	431-434	4
α-helix	437-450	14
β-strand	453	1	36
β-strand	463	1	36
β-strand	468-469	2	30
α-helix	470-471	2
α-helix	475-482	8
β-strand	484	1	37
α-helix	497-499	3
α-helix	503-505	3
β-strand	509	1	38
β-strand	525	1	37
β-strand	526	1	38
α-helix	527	1
β-strand	531-532	2	39
α-helix	539-547	9
β-strand	551-552	2	40
α-helix	558-560	3
β-strand	565-569	5	40
β-strand	572-577	6	40
α-helix	580-592	13
β-strand	602-603	2	40
β-strand	606	1	40
β-strand	611-615	5	40
β-strand	621-627	7	39
β-strand	628-629	2	41
β-strand	632-633	2	41
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	39
α-helix	667-670	4
β-strand	675-676	2	39
α-helix	679-683	5
β-strand	695-696	2	39
α-helix	700-703	4
α-helix	706-709	4
β-strand	717	1	42
α-helix	719-731	13
β-strand	732	1	43
β-strand	748-751	4	44
β-strand	755	1	45
β-strand	759-760	2	46
α-helix	762-765	4
β-strand	776-782	7	47
β-strand	783	1	16
β-strand	794-797	4	47
α-helix	798-802	5
β-strand	808-811	4	44
β-strand	812-817	6	48
β-strand	827-829	3	49
α-helix	831-833	3
β-strand	837	1	49
β-strand	848	1	50
β-strand	853	1	51
β-strand	854	1	50
α-helix	855	1
β-strand	859	1	48
β-strand	865	1	52
β-strand	867	1	51
β-strand	869-872	4	49
α-helix	873	1
β-strand	889-890	2	49
β-strand	895	1	52
β-strand	903-911	9	48
β-strand	917-924	8	48
β-strand	927	1	44
β-strand	934-937	4	47
β-strand	943-949	7	47
β-strand	956-957	2	53
β-strand	965-967	3	47
α-helix	969-971	3
β-strand	977	1	42
α-helix	978-993	16
α-helix	996	1
β-strand	997-998	2	46
α-helix	1008-1017	10
β-strand	1025-1026	2	47
β-strand	1028-1029	2	53
α-helix	1035	1
β-strand	1036	1	53
α-helix	1037	1
β-strand	1041-1050	10	47
β-strand	1051	1	43
α-helix	1055-1058	4
β-strand	1060-1062	3	10
β-strand	1067	1	54
β-strand	1074	1	54
β-strand	1084-1086	3	9
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	1
β-strand	1125	1	1
β-strand	1127-1128	2	55
β-strand	1135-1136	2	55
β-strand	1146-1150	5	1
α-helix	1153-1164	12
β-strand	1170-1172	3	2

Chain C: 11 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
β-strand	8-14	7	56
β-strand	18-24	7	56
α-helix	28-40	13
β-strand	44-55	12	57
α-helix	61-70	10
β-strand	73	1	58
α-helix	83-84	2
β-strand	99-106	8	57
α-helix	112	1
β-strand	113-116	4	59
α-helix	117-119	3
β-strand	121-122	2	57
β-strand	129	1	58
β-strand	149-153	5	59
β-strand	158-168	11	57
α-helix	174-176	3
β-strand	179	1	60
β-strand	184-186	3	56
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-234	6	56
β-strand	235	1	60
α-helix	243-270	28

Chain D: 9 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	61
β-strand	21	1	61
α-helix	29	1
β-strand	30-31	2	26
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-71	13
α-helix	77-89	13
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

Chain E: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	3-24	22
β-strand	26	1	62
α-helix	30-33	4
α-helix	37-43	7
β-strand	60-62	3	63
β-strand	64	1	62
β-strand	72-74	3	63
β-strand	81-82	2	64
α-helix	85-96	12
β-strand	101-106	6	63
β-strand	109-110	2	64
α-helix	112-120	9
β-strand	126-131	6	63
α-helix	132-136	5
α-helix	139-141	3
α-helix	146	1
β-strand	147-151	5	65
α-helix	152	1
α-helix	153-163	11
β-strand	172-173	2	65
α-helix	178-183	6
β-strand	190-195	6	65
β-strand	203-209	7	65

Chain F: 3 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	66
α-helix	59-74	16
β-strand	79	1	27
α-helix	89-98	10
β-strand	104-109	6	26
β-strand	115-119	5	26
β-strand	124	1	66
α-helix	125	1

Chain G: 3 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	3-13	11	26
α-helix	15-17	3
α-helix	22-34	13
β-strand	38-39	2	26
β-strand	43-54	12	26
β-strand	58-59	2	26
α-helix	60	1
β-strand	66-77	12	26
β-strand	84-92	9	67
β-strand	97-101	5	67
β-strand	104-108	5	67
β-strand	117-119	3	68
β-strand	127-130	4	68
β-strand	137-138	2	68
β-strand	142-153	12	67
β-strand	156-162	7	67
β-strand	169-170	2	67

Chain H: 2 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	14
β-strand	22	1	14
β-strand	25-32	8	14
β-strand	39-44	6	14
β-strand	55-61	7	14
β-strand	90-101	12	14
α-helix	108-109	2
β-strand	111	1	69
β-strand	112-118	7	14
β-strand	121-125	5	14
β-strand	128	1	69
α-helix	129-132	4
β-strand	140-145	6	14
β-strand	147	1	14

8 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1984	Sus scrofa	A0A7M4DUC2
DNA-directed RNA polymerase subunit beta	B	protein	1300	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	184	Sus scrofa	A0A287ADR4 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6

7 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8S55_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPT
SPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSY
SPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTS
PKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDS
DEEN

Sequence of entity 2 (B), FASTA

>8S55_2 DNA-directed RNA polymerase subunit beta (chains B)
MKPLRPENPPKAELKGLLFVQQHCKTRLHSVAVTRPRGAATEESTPKLRMCSTNLSQALA
YFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLAVSCVSLRGLGA
PGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMS
VQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEAR
LRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCEL
NECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTST
IWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFED
PEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVS
DFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKE
VRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLT
FASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISV
GSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQM
DIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQ
DLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFP
DHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPA
GINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTR
ETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCST
FLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDM
PFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNL
LSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQP
MEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHT
YECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>8S55_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>8S55_4 RNA polymerase II subunit D (chains D)
MWGPAQPYSDSALSPKPRPFRAVFRGSALPFPAVRVEVRGRSMAAGGSDPRAGDVEEDAS
QLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRE
TIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKR
SFQY

Sequence of entity 5 (E), FASTA

>8S55_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>8S55_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>8S55_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>8S55_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>8S55_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>8S55_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>8S55_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>8S55_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	9

Primary citation

Three-step mechanism of promoter escape by RNA polymerase II. Zhan, Y., Grabbe, F., Oberbeckmann, E. et al. Mol Cell (2024) 84:1699-1710.e6. DOI 10.1016/j.molcel.2024.03.016 · PubMed

Other PDB entries of the same protein (UniProt A0A7M4DUC2), best resolution first:

9BZ0 1.9 Å, Structure of an STK19-containing TC-NER complex
8S52 2.9 Å, RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt
9EGX 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27
9EGY 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27
9EGZ 2.9 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27
7UNC 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome
7UND 3.0 Å, Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38)
8A40 3.0 Å, Structure of mammalian Pol II-TFIIS elongation complex
6TED 3.1 Å, Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers…
9EH2 3.1 Å, RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream
8A3Y 3.3 Å, Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex
9ER2 3.3 Å, PolII-TCR-STK19 structure.

Browse structure collections

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