POU domain, class 2, transcription factor 1 (POU2F1) is a 743-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P14859.
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The mean pLDDT of this model is 49.1 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 74% |
What pLDDT means and how to read it
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR
Interacts with POU2AF1; the interaction increases POU2F1 transactivation activity (PubMed:7859290). Interacts with NR3C1, AR, PGR and HCFC1
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1E3O | X-ray | 1.9 Å | C=280-438 |
| 1GT0 | X-ray | 2.6 Å | C=280-438 |
| 1HF0 | X-ray | 2.7 Å | A/B=280-438 |
| 1OCT | X-ray | 3.0 Å | C=284-439 |
| 1CQT | X-ray | 3.2 Å | A/B=277-439 |
| 1O4X | NMR | A=280-442 | |
| 1POG | NMR | A=378-438 | |
| 1POU | NMR | A=284-354 |
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