Vascular endothelial growth factor A, long form (VEGFA) is a 395-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P15692.
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The mean pLDDT of this model is 63.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 44% |
What pLDDT means and how to read it
Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity)
Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (PubMed:26503042). Interacts with isoform 2 of BSG (PubMed:25825981). Interacts with CD82; this interaction inhibits VEGFA-mediated signaling pathway (PubMed:34530889)
Cytoplasm, Nucleus, Secreted, Endoplasmic reticulum, Golgi apparatus, Secreted, extracellular space, extracellular matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1MKK | X-ray | 1.32 Å | A/B=220-314 |
| 9JU1 | X-ray | 1.45 Å | A=214-315 |
| 9KKU | X-ray | 1.46 Å | A/B=214-315 |
| 4GLN | X-ray | 1.6 Å | E/F=214-315 |
| 4GLS | X-ray | 1.6 Å | E/F=214-315 |
| 6ZBR | X-ray | 1.6 Å | V/W=219-313 |
| 6ZFL | X-ray | 1.6 Å | V/W=219-313 |
| 1FLT | X-ray | 1.7 Å | V/W=218-315 |
| 4KZN | X-ray | 1.71 Å | A=219-315 |
| 4QAF | X-ray | 1.8 Å | C/D=214-315 |
| 6Z13 | X-ray | 1.8 Å | V/W=219-313 |
| 6ZCD | X-ray | 1.8 Å | V/W=219-313 |
| 3QTK | X-ray | 1.85 Å | A/B/C/D/E/F=214-315 |
| 1VPP | X-ray | 1.9 Å | V/W=214-315 |
| 2VPF | X-ray | 1.93 Å | A/B/C/D/E/F/G/H=214-315 |
| 5DN2 | X-ray | 1.95 Å | E/F/G=368-395 |
| 1MJV | X-ray | 2.1 Å | A/B=220-314 |
| 5HHC | X-ray | 2.1 Å | A/B=214-315 |
| 5HHD | X-ray | 2.1 Å | A/B=214-315 |
| 6Z3F | X-ray | 2.1 Å | V/W=219-313 |
Showing 20 of 56 experimental structures (best resolution first).
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