Nucleoprotein (NP) is a 739-residue protein from Zaire ebolavirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P18272.
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The mean pLDDT of this model is 62.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 14% |
| 70 to 90 | Confident: backbone generally right | 40% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response (PubMed:16719918, PubMed:25865894, PubMed:26119732, PubMed:30333622). VP35 binds to and stabilizes monomeric NP, keeping it soluble (PubMed:25865894, PubMed:26119732). Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released (PubMed:29144446). The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm (PubMed:22247782). Each NP binds to six nucleotides of viral genomic…
Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid (PubMed:12191476, PubMed:25865894, PubMed:25910597, PubMed:26119732, PubMed:27755595). Interacts with host PPP2R5C; this interaction leads to VP30 dephosphorylation and viral transcription (PubMed:29290611). Interacts with VP24; this interaction facilitates…
Virion, Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4QB0 | X-ray | 1.75 Å | A=641-739 |
| 4Z9P | X-ray | 1.79 Å | A=36-351 |
| 4QAZ | X-ray | 1.98 Å | A=641-739 |
| 5T3T | X-ray | 2.2 Å | A/B/C/D/E/F/G/H/I/J=600-627 |
| 4ZTA | X-ray | 2.4 Å | A=34-367 |
| 4ZTI | X-ray | 2.4 Å | A/B=34-367 |
| 4ZTG | X-ray | 2.8 Å | A=34-367 |
| 6NUT | EM | 3.1 Å | A=1-450 |
| 4YPI | X-ray | 3.71 Å | A/B/C/D=38-385 |
| 5Z9W | EM | 3.9 Å | A=19-406 |
| 8Y9J | EM | 4.6 Å | A/B=1-739 |
| 6C54 | EM | 5.8 Å | A/B=25-457 |
| 6EHL | EM | 6.6 Å | A=1-739 |
| 6EHM | EM | 7.3 Å | A/B=1-739 |
| 8UST | EM | 7.3 Å | A/B/E=1-739 |
| 8USN | EM | 8.9 Å | A/B/E=1-739 |
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