Erythropoietin receptor (EPOR) is a 508-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P19235.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 66.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (PubMed:10388848, PubMed:2163695, PubMed:2163696, PubMed:8662939, PubMed:9774108). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3 (PubMed:11756159). May also activate the LYN tyrosine kinase (By similarity)
Forms homodimers on EPO stimulation (PubMed:10388848, PubMed:9774108, PubMed:9974392). The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein SH2B2, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3, CRKL (PubMed:12027890, PubMed:7534299). Interacts with INPP5D/SHIP1 (By similarity). SH2B2 binding inhibits the JAK-STAT signaling…
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1EER | X-ray | 1.9 Å | B/C=26-250 |
| 6MOI | X-ray | 2.06 Å | B=32-249 |
| 6MOE | X-ray | 2.09 Å | C/D=32-249 |
| 8VUI | X-ray | 2.1 Å | D=25-250 |
| 1ERN | X-ray | 2.4 Å | A/B=34-246 |
| 6MOJ | X-ray | 2.43 Å | B=32-249 |
| 4Y5V | X-ray | 2.6 Å | C/F/I=32-249 |
| 6E2Q | X-ray | 2.65 Å | M/N/O/P=273-338 |
| 6I4X | X-ray | 2.69 Å | D=422-432 |
| 1EBA | X-ray | 2.7 Å | A/B=34-248 |
| 1CN4 | X-ray | 2.8 Å | A/B=24-249 |
| 1EBP | X-ray | 2.8 Å | A/B=34-244 |
| 4Y5Y | X-ray | 2.85 Å | C/F=32-249 |
| 6MOF | X-ray | 2.89 Å | B=32-249 |
| 8VVM | X-ray | 2.9 Å | I=25-250 |
| 8VVO | X-ray | 3.09 Å | I=25-250 |
| 4Y5X | X-ray | 3.15 Å | C/F/I/L=32-249 |
| 6MOL | X-ray | 3.16 Å | B/C=32-249 |
| 2JIX | X-ray | 3.2 Å | B/C/E=25-249 |
| 6MOH | X-ray | 3.2 Å | C/D=32-249 |
Showing 20 of 22 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.