Sodium/hydrogen exchanger 1 (SLC9A1) is a 815-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P19634.
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The mean pLDDT of this model is 67.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511,…
Homodimer; dimerization is crucial for its function (PubMed:15323573, PubMed:17073455, PubMed:34108458). Oligomer (By similarity). Interacts with CALM1 in a calcium-dependent manner (PubMed:12809501, PubMed:18757828, PubMed:30287853). Interacts with TESC (PubMed:11696366, PubMed:12809501, PubMed:30287853). Interacts (via the C-terminal domain) with CHP1; the interaction occurs at the plasma…
Cell membrane, Basolateral cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6NUC | X-ray | 1.9 Å | C=679-723 |
| 6NUF | X-ray | 1.9 Å | C=679-723 |
| 9NXE | X-ray | 2.09 Å | C=679-723 |
| 2YGG | X-ray | 2.23 Å | A=622-689 |
| 6NUU | X-ray | 2.3 Å | C=679-723 |
| 2BEC | X-ray | 2.7 Å | B=503-545 |
| 23XK | EM | 3.1 Å | A/B=1-815 |
| 23XO | EM | 3.16 Å | A/B=1-815 |
| 23XM | EM | 3.24 Å | A/B=1-815 |
| 7DSW | EM | 3.3 Å | A/B=87-506 |
| 7DSV | EM | 3.4 Å | A/B=87-558 |
| 7DSX | EM | 3.5 Å | A/B=85-593 |
| 1Y4E | NMR | A=155-180 | |
| 2E30 | NMR | B=503-545 | |
| 2HTG | NMR | A=250-274 | |
| 2KBV | NMR | A=447-472 | |
| 2L0E | NMR | A=226-250 | |
| 2MDF | NMR | A=226-274 | |
| 6BJF | NMR | A=431-443 | |
| 6ZBI | NMR | B/C=622-657 |
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