Integrin alpha-X (ITGAX) is a 1163-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P20702.
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The mean pLDDT of this model is 88.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis (PubMed:16985175)
Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1N3Y | X-ray | 1.65 Å | A=147-338 |
| 4NEH | X-ray | 2.75 Å | A=20-1101 |
| 4NEN | X-ray | 2.9 Å | A=20-1101 |
| 5ES4 | X-ray | 3.3 Å | A/C/E/G=20-1103 |
| 3K6S | X-ray | 3.5 Å | A/C/E/G=20-1103 |
| 3K72 | X-ray | 3.7 Å | A/C=20-1103 |
| 3K71 | X-ray | 3.95 Å | A/C/E/G=20-1103 |
| 2LUV | NMR | A=1129-1163 | |
| 9ECM | NMR | A=1098-1138 |
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