Interleukin-11 (IL11) is a 199-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P20809.
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The mean pLDDT of this model is 82.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 20% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'…
Interacts with IL11RA to associate with IL6ST, giving rise to a multimeric signaling complex
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8DPV | X-ray | 1.48 Å | A=32-199 |
| 6O4O | X-ray | 1.62 Å | A=32-199 |
| 8DPW | X-ray | 1.8 Å | A=32-199 |
| 4MHL | X-ray | 2.09 Å | A=23-199 |
| 8QY4 | EM | 3.06 Å | A/D=1-199 |
| 8DPS | EM | 3.47 Å | B/E=32-199 |
| 8DPU | X-ray | 3.78 Å | B/E/H/K/N/Q=22-199 |
| 8DPT | EM | 4.0 Å | B/E=32-199 |
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