8DPW: Interleukin-11 Mutein

Name: PDB 8DPW: The structure of Interleukin-11 Mutein
Published: 2023-11-29
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: cytokine

The structure of Interleukin-11 Mutein. Determined by X-ray diffraction at 1.8 Å resolution. Released 29 Nov 2023.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,366
Mol. weight: 18.4 kDa
Released: 29 Nov 2023

Explore 8DPW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8DPW contains 8 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	14-42	29
α-helix	51-53	3
α-helix	58-60	3
α-helix	69-93	25
α-helix	96-101	6
α-helix	102-125	24
α-helix	128-143	16
α-helix	146-175	30

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-11	A	protein	169	Homo sapiens	P20809 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8DPW_1 Interleukin-11 (chains A)
GSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLPAIDYALGALQL
PGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALP
QPPPDPPAPPLAPPSSAAGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL

Primary citation

Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Metcalfe, R.D., Hanssen, E., Fung, K.Y. et al. Nat Commun (2023) 14:7543-7543. DOI 10.1038/s41467-023-42754-w · PubMed

Other PDB entries of the same protein (UniProt P20809 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8DPV 1.48 Å, The crystal structure of Interleukin-11, W147A mutant
6O4O 1.62 Å, The structure of human interleukin 11
4MHL 2.09 Å, The crystal structure of human interleukin-11
8QY4 3.06 Å, Structure of interleukin 11 (gp130 P496L mutant).
8DPS 3.47 Å, The structure of the interleukin 11 signalling complex, truncated gp130
8DPU 3.78 Å, The crystal structure of the IL-11 signalling complex
8DPT 4.0 Å, The structure of the IL-11 signalling complex, with full-length extracellular gp130

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