Streptavidin is a 183-residue protein from Streptomyces avidinii. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P22629.
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The mean pLDDT of this model is 84.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin)
Homotetramer
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2F01 | X-ray | 0.85 Å | A/B=37-163 |
| 9PUA | X-ray | 0.94 Å | J/L=37-163 |
| 3RY2 | X-ray | 0.95 Å | A/B=37-163 |
| 9PUB | X-ray | 0.95 Å | J/K=37-163 |
| 1LUQ | X-ray | 0.96 Å | A/B=37-163 |
| 2GH7 | X-ray | 1.0 Å | A/B=37-163 |
| 3WYQ | X-ray | 1.0 Å | A/B=37-163 |
| 4GDA | X-ray | 1.0 Å | A/B=73-168 |
| 6T2L | X-ray | 1.0 Å | A=38-183 |
| 3RY1 | X-ray | 1.03 Å | A/B/C/D=37-163 |
| 5N8B | X-ray | 1.03 Å | A/B/D/G=1-183 |
| 5N8J | X-ray | 1.05 Å | A/B/C/D=1-183 |
| 4CPE | X-ray | 1.06 Å | A/B=37-163 |
| 6GH7 | X-ray | 1.08 Å | A/B/C/D=37-163 |
| 5N8E | X-ray | 1.1 Å | A/B/C/D=1-183 |
| 5N8W | X-ray | 1.1 Å | A/B=1-183 |
| 7EK9 | X-ray | 1.1 Å | A/B/C/D=38-160 |
| 5N7X | X-ray | 1.12 Å | A/B/E/F/H/K/M/O=1-183 |
| 9CST | X-ray | 1.13 Å | A=38-183 |
| 1RXJ | X-ray | 1.14 Å | A/B/C/D=39-159 |
Showing 20 of 314 experimental structures (best resolution first).
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