C-X-C chemokine receptor type 2 (CXCR2) is a 360-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P25025.
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The mean pLDDT of this model is 79.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 42% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (PubMed:1891716). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site
Interacts with IL8 (PubMed:1891716). Interacts with GNAI2 (PubMed:8662698)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4Q3H | X-ray | 1.44 Å | A/B=356-360 |
| 6KVA | X-ray | 2.2 Å | B/b=9-19 |
| 5TYT | X-ray | 2.4 Å | A/B/C/D=356-360 |
| 6KVF | X-ray | 2.79 Å | B/b=9-19 |
| 8XXH | EM | 2.8 Å | R=2-360 |
| 8XX6 | EM | 2.99 Å | R=2-360 |
| 8XWS | EM | 3.06 Å | C/R=2-360 |
| 8XWV | EM | 3.07 Å | R=2-360 |
| 8XVU | EM | 3.09 Å | R=2-360 |
| 8XXR | EM | 3.17 Å | R=2-360 |
| 8XXX | EM | 3.17 Å | R=2-360 |
| 6LFL | X-ray | 3.2 Å | A=37-241, A=244-344 |
| 8XWN | EM | 3.29 Å | R=2-360 |
| 8XX7 | EM | 3.32 Å | C/R=2-360 |
| 8XX3 | EM | 3.38 Å | R=2-360 |
| 6LFO | EM | 3.4 Å | R=1-360 |
| 8XWA | EM | 3.48 Å | R=2-360 |
| 6LFM | EM | 3.5 Å | R=1-360 |
| 8XWF | EM | 3.65 Å | R=2-360 |
| 8XWM | EM | 3.71 Å | R=2-360 |
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