Integrin beta-7 (ITGB7) is a 798-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P26010.
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The mean pLDDT of this model is 83.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 41% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract (PubMed:10837471, PubMed:14608374). Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable).…
Heterodimer of an alpha and a beta subunit (PubMed:1542691, PubMed:38781659). ITGB7/beta-7 associates with either ITGA4/alpha-4 or ITGAE/alpha-E (PubMed:1542691, PubMed:38781659). In the absence of the E-cadherin ligand, the ITGAE/ITGB7 (alpha-E/beta-7) heterodimer shows an overall half-bent conformation, an intermediate between closed and open conformations, with the alpha-I domain of…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2BRQ | X-ray | 2.1 Å | C/D=768-798 |
| 8ZJF | EM | 2.7 Å | B=2-798 |
| 9P97 | EM | 2.92 Å | B=1-723 |
| 9P98 | EM | 2.93 Å | B=1-723 |
| 9P95 | EM | 3.05 Å | B=1-723 |
| 3V4V | X-ray | 3.1 Å | B/D=20-512 |
| 9P96 | EM | 3.1 Å | B=101-473 |
| 3V4P | X-ray | 3.15 Å | B/D=20-512 |
| 9P99 | EM | 3.37 Å | B=1-723 |
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