Protein S100-A4 (S100A4) is a 101-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P26447.
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The mean pLDDT of this model is 86.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197).…
Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (PubMed:11836260). Interacts with PGLYRP1; this complex acts as a chemoattractant that promotes lymphocyte movement (PubMed:26654597, PubMed:30713770). Interacts with MYH9; this interaction increases cell motility (PubMed:16707441). Interacts with Annexin 2/ANXA2 (PubMed:28669632). Interacts with TP53; this interaction promotes TP53…
Secreted, Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4CFQ | X-ray | 1.37 Å | A/B/C/D=1-88 |
| 4CFR | X-ray | 1.4 Å | A/B=1-101 |
| 3C1V | X-ray | 1.5 Å | A/B/C/D=1-101 |
| 4ETO | X-ray | 1.54 Å | A/B=1-93 |
| 2Q91 | X-ray | 1.63 Å | A/B=1-101 |
| 7PSQ | X-ray | 1.91 Å | A/C/E/G=1-100 |
| 3ZWH | X-ray | 1.94 Å | A/B=1-101 |
| 3CGA | X-ray | 2.03 Å | A/B=1-101 |
| 5LPU | X-ray | 2.1 Å | C/D=1-101 |
| 4HSZ | X-ray | 2.25 Å | A/B/C/D=1-93 |
| 3KO0 | X-ray | 2.3 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-101 |
| 7PSP | X-ray | 2.61 Å | A/B=1-100 |
| 3M0W | X-ray | 2.8 Å | A/B/C/D/E/F/G/H/I/J=2-101 |
| 6T58 | X-ray | 3.1 Å | A/B=1-93 |
| 1M31 | NMR | A/B=1-101 | |
| 2LNK | NMR | A/B=1-101 | |
| 2MRD | NMR | A/B=1-101 |
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