14-3-3 protein theta (YWHAQ) is a 245-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P27348.
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The mean pLDDT of this model is 93.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1
Homodimer. Forms heterodimers with SFN, YWHAG or YWHAB (By similarity). Interacts with CDK16 (By similarity). Interacts with RGS7 (phosphorylated form) (PubMed:10862767). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with…
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6BCR | X-ray | 1.99 Å | A/B/E/F=1-245 |
| 6KZG | X-ray | 2.0 Å | A/B=2-234 |
| 5IQP | X-ray | 2.6 Å | A/B=1-245 |
| 6KZH | X-ray | 2.65 Å | A/B=2-234 |
| 2BTP | X-ray | 2.8 Å | A/B=1-234 |
| 6BQT | X-ray | 2.8 Å | A/B/D/E/G/H/J/K=1-245 |
| 6BD2 | X-ray | 2.9 Å | A/B=1-245 |
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