6KZG: 14-3-3 protein

14-3-3 protein in Complex with CIC S301 phosphorylated peptide. Determined by X-ray diffraction at 2.0 Å resolution. Released 30 Sept 2020.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 4
Atoms: 3,962
Mol. weight: 61.61 kDa
Released: 30 Sept 2020

Explore 6KZG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6KZG contains 29 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 0 β-strands

Element	Residues	Length
α-helix	1-15	15
α-helix	19-30	12
α-helix	35-37	3
α-helix	38-68	31
α-helix	76-100	25
α-helix	101-105	5
α-helix	112-131	20
α-helix	136-159	24
α-helix	165-176	12
α-helix	177-181	5
α-helix	185-200	16
α-helix	211-228	18

Chain B: 15 helices, 0 β-strands

Element	Residues	Length
α-helix	1-16	16
α-helix	19-30	12
α-helix	35-37	3
α-helix	38-67	30
α-helix	76-100	25
α-helix	101-105	5
α-helix	106-108	3
α-helix	112-132	21
α-helix	135-159	25
α-helix	165-176	12
α-helix	177-181	5
α-helix	185-201	17
α-helix	203-205	3
α-helix	208-210	3
α-helix	211-228	18

Chains C and Q: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	302-304	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
14-3-3 protein theta	A, B	protein	263	Homo sapiens	P27348 (AlphaFold model)
Arg-ser-met-ser-glu-thr-gly-thr	C, Q	protein	8	Homo sapiens	Q96RK0 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>6KZG_1 14-3-3 protein theta (chains A, B)
MGSSHHHHHHSSGLVPRGSHMASENLYFQGEKTELIQKAKLAEQAERYDDMATCMKAVTE
QGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELR
SICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQE
AFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSY
KDSTLIMQLLRDNLTLWTSDSAG

Sequence of entity 2 (C, Q), FASTA

>6KZG_2 ARG-SER-MET-SER-GLU-THR-GLY-THR (chains C, Q)
RSMSETGT

Primary citation

14-3-3 protein in Complex with CIC S301 phosphorylated peptide. Wen, Y., Shao, Y. To be published.

Other PDB entries of the same protein (UniProt P27348 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6BCR 1.99 Å, Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T340
6BCY 2.3 Å, Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T360
6BD1 2.35 Å, Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at S366
5IQP 2.6 Å, 14-3-3 protein tau isoform
6KZH 2.65 Å, 14-3-3 protein in Complex with CIC S173 phosphorylated peptide
2BTP 2.8 Å, 14-3-3 Protein Theta (Human) Complexed to Peptide
6BQT 2.8 Å, Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and T360
6BD2 2.9 Å, Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and S366

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