Protein translocase subunit SecA (secA) is a 841-residue protein from Bacillus subtilis (strain 168). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P28366.
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The mean pLDDT of this model is 87.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may be involved. Monomer and many different homodimers can be isolated (PubMed:16989859), some of which are not formed in the presence of a synthetic signal peptide. A single SecA monomer interacts with SecY in the channel. Only shows some colocalization with FloA…
Cell membrane, Cytoplasm, Membrane raft
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1TF5 | X-ray | 2.18 Å | A=1-841 |
| 3JV2 | X-ray | 2.5 Å | A/B=1-780 |
| 1M6N | X-ray | 2.7 Å | A=1-802 |
| 1TF2 | X-ray | 2.9 Å | A=1-841 |
| 8YA0 | EM | 2.97 Å | A=14-778 |
| 1M74 | X-ray | 3.0 Å | A=1-802 |
| 2IBM | X-ray | 3.2 Å | A/B=1-780 |
| 8Y9Y | EM | 3.29 Å | A=1-778 |
| 3IQY | X-ray | 3.3 Å | A=1-841 |
| 7XHB | EM | 3.33 Å | A=1-778 |
| 7XHA | EM | 3.35 Å | A=1-778 |
| 3IQM | X-ray | 3.4 Å | A=1-802 |
| 8Y9Z | EM | 3.41 Å | A=1-778 |
| 6ITC | EM | 3.45 Å | A=1-780 |
| 5EUL | X-ray | 3.7 Å | A=1-780 |
| 8YA2 | EM | 3.84 Å | A=1-778 |
| 8YAS | EM | 3.97 Å | A=1-778 |
| 3DL8 | X-ray | 7.5 Å | A/B=1-779 |
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