General transcription factor IIE subunit 1 (GTF2E1) is a 439-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P29083.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 66.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 3% |
| 70 to 90 | Confident: backbone generally right | 51% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase
Tetramer of two alpha and two beta chains (PubMed:1956398). Interacts with TAF6/TAFII80 (PubMed:7667268). Interacts with ATF7IP (PubMed:19106100). Interacts with SND1 (PubMed:7651391). Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1,…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5GPY | X-ray | 2.1 Å | A=1-217 |
| 7NVU | EM | 2.5 Å | W=1-439 |
| 7NVS | EM | 2.8 Å | W=1-439 |
| 7NVT | EM | 2.9 Å | W=1-439 |
| 7NVV | EM | 2.9 Å | W=1-439 |
| 8S52 | EM | 2.9 Å | W=1-439 |
| 8S51 | EM | 3.1 Å | W=1-439 |
| 7EGB | EM | 3.3 Å | U=1-439 |
| 8S54 | EM | 3.4 Å | W=1-439 |
| 8S55 | EM | 3.4 Å | W=1-439 |
| 8S5N | EM | 3.4 Å | W=1-439 |
| 7EG9 | EM | 3.7 Å | U=1-439 |
| 5IYB | EM | 3.9 Å | Q=1-439 |
| 5IYC | EM | 3.9 Å | Q=1-439 |
| 5IYD | EM | 3.9 Å | Q=1-439 |
| 7EGC | EM | 3.9 Å | U=1-439 |
| 7NVX | EM | 3.9 Å | W=1-439 |
| 8BVW | EM | 4.0 Å | W=1-439 |
| 7ENA | EM | 4.07 Å | EA=1-439 |
| 7EGA | EM | 4.1 Å | U=1-439 |
Showing 20 of 48 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.