Casein kinase I homolog HRR25 (HRR25) is a 494-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P29295.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 81.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Protein kinase which phosphorylates serine and threonine residues (PubMed:1495994). Can use casein as a substrate (PubMed:1495994). Phosphorylates elongator complex member ELP1/IKI3 on 'Ser-1198' and 'Ser-1202' which promotes the tRNA modification function of the complex (PubMed:25569479). Associated with repair of damaged DNA and meiosis (PubMed:1887218)
Interacts with HRI1 (PubMed:21460040). Interacts with ELP1/IKI3; the interaction leads to ELP1/IKI3 phosphorylation (PubMed:21460040)
Cytoplasm, Nucleus, nucleolus, Nucleus, nucleoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5CYZ | X-ray | 1.84 Å | A=1-394 |
| 5CZO | X-ray | 2.89 Å | A/B=1-394 |
| 4XHL | X-ray | 3.01 Å | A=1-394 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.