Type-1 angiotensin II receptor (AGTR1) is a 359-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30556.
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The mean pLDDT of this model is 82.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768, PubMed:8987975). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:15611106)
Interacts with MAS1 (PubMed:15809376). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6OS2 | X-ray | 2.7 Å | A=2-319 |
| 6OS1 | X-ray | 2.79 Å | A=2-319 |
| 4ZUD | X-ray | 2.8 Å | A=15-315 |
| 4YAY | X-ray | 2.9 Å | A=15-319 |
| 6DO1 | X-ray | 2.9 Å | A/B=2-319 |
| 6OS0 | X-ray | 2.9 Å | A=2-319 |
| 8TH3 | EM | 3.0 Å | A/B=2-226, A/B=235-319 |
| 9EAH | EM | 3.1 Å | A/B=2-231, A/B=235-319 |
| 9EAI | EM | 3.1 Å | A/B=2-231, A/B=235-319 |
| 9EAJ | EM | 3.2 Å | A/B=2-231, A/B=235-319 |
| 8TH4 | EM | 3.3 Å | A=2-226, A=235-319 |
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