CAP-Gly domain-containing linker protein 1 (CLIP1) is a 1438-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30622.
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The mean pLDDT of this model is 71.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 53% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking
Interacts with MTOR; phosphorylates and regulates CLIP1 (PubMed:12231510). Interacts (via CAP-Gly domains) with tubulin (PubMed:17563362, PubMed:17889670). Interacts with SLAIN2 (PubMed:21646404). Interacts (via zinc finger) with DCTN1 (PubMed:17828275, PubMed:20679239). Interacts with TUBA1B, MAPRE1 and MAPRE3 (PubMed:17563362). Binds preferentially to tyrosinated microtubules, and only…
Cytoplasm, Cytoplasm, cytoskeleton, Cytoplasmic vesicle membrane, Cell projection, ruffle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2E3H | X-ray | 1.45 Å | A=211-300 |
| 3RDV | X-ray | 1.75 Å | A/B/C/D=56-127 |
| 2HQH | X-ray | 1.8 Å | E/F/G/H=1416-1438 |
| 8WHI | X-ray | 1.85 Å | E/F=350-456 |
| 2E3I | X-ray | 2.0 Å | A=56-141 |
| 2QK0 | X-ray | 2.0 Å | A=57-128 |
| 3E2U | X-ray | 2.6 Å | E/F/G/H=1399-1438 |
| 8WHH | X-ray | 3.8 Å | E/F/G/H=350-456 |
| 2CP5 | NMR | A=1-128 | |
| 2CP6 | NMR | A=181-339 | |
| 2E4H | NMR | A=203-300 |
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