2HQH: P150Glued and CLIP-170

Crystal structure of p150Glued and CLIP-170. Determined by X-ray diffraction at 1.8 Å resolution. Released 21 Aug 2007.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Homo sapiens
Chains: 8
Atoms: 3,429
Mol. weight: 51.69 kDa
Ligands: ZN
Released: 21 Aug 2007

Explore 2HQH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2HQH contains 8 α-helices and 40 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C and D: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	32-35	4	1
β-strand	41-48	8	1
β-strand	57-62	6	1
β-strand	69	1	1
β-strand	72-73	2	2
β-strand	76-77	2	2
β-strand	86-89	4	1
α-helix	91-93	3
β-strand	94-96	3	1

Chains E, F, G and H: 1 helix, 2 β-strands

Element	Residues	Length	Sheet
β-strand	1407-1408	2	9
β-strand	1413-1414	2	9
α-helix	1418-1420	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Dynactin-1	A, B, C, D	protein	93	Homo sapiens	Q14203 (AlphaFold model)
Restin	E, F, G, H	protein	25	Homo sapiens	P30622 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>2HQH_1 Dynactin-1 (chains A, B, C, D)
GSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQ
GRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPE

Sequence of entity 2 (E, F, G, H), FASTA

>2HQH_2 Restin (chains E, F, G, H)
GSRPYCEICEMFGHWATNCNDDETF

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	4

Primary citation

CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1. Hayashi, I., Plevin, M.J., Ikura, M. Nat Struct Mol Biol (2007) 14:980-981. DOI 10.1038/nsmb1299 · PubMed

Other PDB entries of the same protein (UniProt Q14203 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1TXQ 1.8 Å, Crystal structure of the EB1 C-terminal domain complexed with the CAP-Gly domain of…
2HKQ 1.86 Å, Crystal structure of the C-terminal domain of human EB1 in complex with the CAP-Gly…
2HKN 1.87 Å, Crystal structure of the CAP-Gly domain of human Dynactin-1 (p150-Glued)
2HL5 1.93 Å, Crystal structure of the C-terminal domain of human EB1 in complex with the A49M mutant…
2HL3 2.03 Å, Crystal structure of the A49M mutant CAP-Gly domain of human Dynactin-1 (p150-Glued) in…
3TQ7 2.3 Å, EB1c/EB3c heterodimer in complex with the CAP-Gly domain of P150glued
3E2U 2.6 Å, Crystal structure of the zink-knuckle 2 domain of human CLIP-170 in complex with CAP-Gly…
9B7J 3.49 Å, Cryo-EM structure of human dynactin complex bound to Chlamydia effector Dre1
9YND 4.26 Å, Motor domain of human dynein-1 in pre-power stroke bound to dynactin-p150glued-CC1B and…
9YNH 5.5 Å, Full-length human cytoplasmic dynein-1 in phi-like state bound to dynactin-p150glued and…
9YNE 8.46 Å, Motor domain of human dynein-1 in pre-power stroke bound to dynactin-p150glued-CC1B-ICD…
2COY Solution structure of the CAP-Gly domain in human Dynactin 1

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