DNA-directed RNA polymerase II subunit RPB2 (POLR2B) is a 1174-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30876.
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The mean pLDDT of this model is 89.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain…
Component of the RNA polymerase II (Pol II) core complex consisting of 12 subunits: a ten-subunit catalytic core composed of POLR2A/RPB1, POLR2B/RPB2, POLR2C/RPB3, POLR2I/RPB9, POLR2J/RPB11, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5 and a mobile stalk composed of two subunits POLR2D/RPB4 and POLR2G/RPB7, protruding from the core and functioning primarily in…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9EHZ | EM | 2.6 Å | B=1-1174 |
| 8XSO | EM | 2.7 Å | B=1-1174 |
| 8XRM | EM | 3.13 Å | B=1-1174 |
| 9EI1 | EM | 3.2 Å | B=1-1174 |
| 9EI3 | EM | 3.2 Å | B=1-1174 |
| 8XRJ | EM | 3.6 Å | B=1-1174 |
| 9EI4 | EM | 3.7 Å | B=1-1174 |
| 5IYB | EM | 3.9 Å | B=1-1174 |
| 5IYC | EM | 3.9 Å | B=1-1174 |
| 5IYD | EM | 3.9 Å | B=1-1174 |
| 6DRD | EM | 3.9 Å | B=1-1174 |
| 8XVS | EM | 4.1 Å | B=1-1174 |
| 6XRE | EM | 4.6 Å | B=1-1174 |
| 7LBM | EM | 4.8 Å | B=1-1174 |
| 5IYA | EM | 5.4 Å | B=1-1174 |
| 5IY9 | EM | 6.3 Å | B=1-1174 |
| 5IY6 | EM | 7.2 Å | B=1-1174 |
| 6O9L | EM | 7.2 Å | B=1-1174 |
| 5IY8 | EM | 7.9 Å | B=1-1174 |
| 5IY7 | EM | 8.6 Å | B=1-1174 |
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