S-M checkpoint control protein rad4 (rad4) is a 648-residue protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32372.
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The mean pLDDT of this model is 68.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis (PubMed:7957098, PubMed:8343962). Interacts simultaneously with both 'Thr-187' phosphorylation sites in a crb2 dimer for establishing the DNA checkpoint (PubMed:24074952)
Interacts with drc1/sld2 (PubMed:11937031). Interacts (via BRCT1,2 domains) with crb2 (PubMed:9407031, PubMed:14739927); a single rad4 molecule interacts simultaneously with both 'Thr-187' phosphorylation sites in a crb2 dimer (PubMed:24074952)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4BU0 | X-ray | 1.5 Å | A=1-186 |
| 6HM3 | X-ray | 1.77 Å | A=1-186 |
| 6HM4 | X-ray | 1.77 Å | A=1-186 |
| 4BMC | X-ray | 1.98 Å | A=1-186 |
| 4BU1 | X-ray | 2.1 Å | A/B=1-186 |
| 4BMD | X-ray | 2.5 Å | A=291-494 |
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