Transcription initiation factor IIA large subunit (TOA1) is a 286-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32773.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 65.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 20% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
TFIIA is a component of the transcription machinery of RNA polymerase II and implicated in the regulation of basal transcription. Interacts with TBP (the TATA-binding protein)
TFIIA is a heterodimer composed of the large TOA1 and a small TOA2 subunits. Interacts with KAP122
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1NH2 | X-ray | 1.9 Å | B=2-54, C=210-286 |
| 1RM1 | X-ray | 2.5 Å | C=1-286 |
| 1YTF | X-ray | 2.5 Å | B=2-54, C=210-286 |
| 7O4J | EM | 2.9 Å | U=1-286 |
| 7OHA | EM | 2.9 Å | L=1-286 |
| 7OH9 | EM | 3.0 Å | L=1-286 |
| 8CEN | EM | 3.0 Å | U=1-286 |
| 7ML4 | EM | 3.1 Å | U=1-286 |
| 7ZS9 | EM | 3.1 Å | U=1-286 |
| 7O4I | EM | 3.2 Å | U=1-286 |
| 7O75 | EM | 3.2 Å | U=1-286 |
| 7ML2 | EM | 3.4 Å | U=1-286 |
| 7O72 | EM | 3.4 Å | U=1-286 |
| 7O73 | EM | 3.4 Å | U=1-286 |
| 8CEO | EM | 3.6 Å | U=1-286 |
| 8UMI | EM | 3.7 Å | U=1-286 |
| 8UOT | EM | 3.7 Å | U=1-286 |
| 8UOQ | EM | 3.8 Å | U=1-286 |
| 7ML1 | EM | 4.0 Å | U=1-286 |
| 7ZSA | EM | 4.0 Å | U=1-286 |
Showing 20 of 31 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.