P32790: Actin cytoskeleton-regulatory complex protein SLA1 (SLA1)

Actin cytoskeleton-regulatory complex protein SLA1 (SLA1) is a 1244-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32790.

Gene
SLA1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
1244 residues
Mean pLDDT
56.2
Model
AF-P32790-F1 v6
Model created
1 Aug 2025
PDB structures
7

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Model confidence (pLDDT)

The mean pLDDT of this model is 56.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate18%
70 to 90Confident: backbone generally right19%
50 to 70Low: treat with caution4%
Below 50Very low: often disordered regions60%

What pLDDT means and how to read it

Function

Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization

Subunit structure

Component of the PAN1 actin cytoskeleton-regulatory complex. Interacts with ABP1, KRE6, LAS17, LSB5, RSP5, RVS167, VPS1 and YSC84

Subcellular location

Nucleus, Cell membrane, Endosome membrane, Cytoplasm, cytoskeleton, actin patch

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
2V1QX-ray1.2 ÅA/B=356-413
1SSHX-ray1.4 ÅB=191-202
9HDBX-ray1.49 ÅA/B=355-414
3IDWX-ray1.85 ÅA=653-724
1Z9ZX-ray1.95 ÅA/B=357-413
2HBPNMRA=495-560
2JT4NMRA=350-420

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