GTP-binding nuclear protein GSP1/CNR1 (GSP1) is a 219-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32835.
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The mean pLDDT of this model is 88.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. By analogy with Ras, Ran may be activated when GTP is exchanged for bound GDP by RCC1 and inactivated when GTP is hydrolyzed by Ran upon activation by RanGAP1. Also participates in nucleosome assembly by stimulating the release of histone H2A-H2B dimers from their nuclear import chaperone KAP114, to facilitate their deposition into nucleosomes by NAP1 (PubMed:39601790)
Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity). Forms a complex with YRB1 (PubMed:10921930). Interacts with NAP1; for the nuclear import of histone H2A-H2B dimers and their assembly into nucleosomes (PubMed:39601790). Interacts with histones H2A and H2B; for the nuclear import of histone H2A-H2B dimers and their assembly into nucleosomes (PubMed:39601790).…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3M1I | X-ray | 2.0 Å | A=1-219 |
| 3WYG | X-ray | 2.15 Å | A=1-182 |
| 2X19 | X-ray | 2.8 Å | A=8-179 |
| 9B3I | EM | 2.88 Å | D=2-179 |
| 8QYZ | X-ray | 3.0 Å | A/B/E/G=1-182 |
| 9D45 | EM | 3.1 Å | B=2-179 |
| 9DZ6 | EM | 3.1 Å | B=2-179 |
| 3ICQ | X-ray | 3.2 Å | B/C=9-179 |
| 9DXM | EM | 3.2 Å | B=2-179 |
| 9OGB | EM | 3.25 Å | B=1-179 |
| 8F1E | EM | 3.28 Å | D=1-179 |
| 8F19 | EM | 3.49 Å | B=1-179 |
| 8F7A | EM | 3.78 Å | B=1-219 |
| 8DYO | EM | 7.1 Å | B=1-219 |
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