General transcription factor IIF subunit 1 (GTF2F1) is a 517-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35269.
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The mean pLDDT of this model is 62.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation
Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1. Interacts with GTF2B (via C-terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2 (PubMed:12931194, PubMed:8662660). Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1I27 | X-ray | 1.02 Å | A=449-517 |
| 1F3U | X-ray | 1.7 Å | B/D/F/H=2-172 |
| 1J2X | X-ray | 2.0 Å | A=449-517 |
| 7NVU | EM | 2.5 Å | Q=1-517 |
| 8WAV | EM | 2.72 Å | S=1-517 |
| 8WAX | EM | 2.75 Å | S=1-517 |
| 8WAZ | EM | 2.76 Å | S=1-517 |
| 8WAU | EM | 2.78 Å | S=1-517 |
| 7NVS | EM | 2.8 Å | Q=1-517 |
| 8WAT | EM | 2.82 Å | S=1-517 |
| 8WAY | EM | 2.85 Å | S=1-517 |
| 7NVT | EM | 2.9 Å | Q=1-517 |
| 8S52 | EM | 2.9 Å | Q=1-517 |
| 8WB0 | EM | 2.94 Å | S=1-517 |
| 7ZWD | EM | 3.0 Å | Q=1-517 |
| 7ZX8 | EM | 3.0 Å | Q=1-517 |
| 8WAW | EM | 3.02 Å | S=1-517 |
| 8S51 | EM | 3.1 Å | Q=1-517 |
| 7EGB | EM | 3.3 Å | S=1-517 |
| 7ZX7 | EM | 3.4 Å | Q=1-517 |
Showing 20 of 61 experimental structures (best resolution first).
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