Eukaryotic initiation factor 4A-III (EIF4A3) is a 411-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P38919.
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The mean pLDDT of this model is 88.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:16170325, PubMed:16209946, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of…
Identified in the spliceosome C complex (PubMed:11991638, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961). Core component of the mRNA splicing-dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A (PubMed:14730019, PubMed:15034551, PubMed:16170325, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377,…
Nucleus, Nucleus speckle, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4C9B | X-ray | 2.0 Å | A=1-411 |
| 2J0S | X-ray | 2.21 Å | A=2-411 |
| 2HYI | X-ray | 2.3 Å | C/I=1-411 |
| 3EX7 | X-ray | 2.3 Å | C/H=1-411 |
| 7ZNJ | EM | 2.4 Å | A/F/K/a/f/k=23-404 |
| 8C6J | EM | 2.8 Å | 7=1-411 |
| 2J0U | X-ray | 3.0 Å | A/B=38-411 |
| 6ICZ | EM | 3.0 Å | u=1-411 |
| 6YVH | X-ray | 3.19 Å | H/J/K/L=246-411 |
| 2J0Q | X-ray | 3.2 Å | A/B=2-411 |
| 2HXY | X-ray | 3.3 Å | A/B/C/D=23-411 |
| 6QDV | EM | 3.3 Å | 7=22-411 |
| 9FMD | EM | 3.3 Å | 7=1-411 |
| 2XB2 | X-ray | 3.4 Å | A/X=1-411 |
| 8I0W | EM | 3.4 Å | u=1-411 |
| 5XJC | EM | 3.6 Å | u=1-411 |
| 7W59 | EM | 3.6 Å | u=1-411 |
| 7W5A | EM | 3.6 Å | u=1-411 |
| 5YZG | EM | 4.1 Å | u=1-411 |
| 7W5B | EM | 4.3 Å | u=1-411 |
Showing 20 of 22 experimental structures (best resolution first).
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