Transcription factor ETV6 (ETV6) is a 452-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41212.
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The mean pLDDT of this model is 61.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 48% |
What pLDDT means and how to read it
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation
Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9DOC | X-ray | 1.19 Å | A=47-121 |
| 9ZB7 | X-ray | 1.24 Å | A=47-124 |
| 9Q4D | X-ray | 1.3 Å | A=47-125 |
| 7TW9 | X-ray | 1.41 Å | A=47-123 |
| 1JI7 | X-ray | 1.45 Å | A/B/C=47-123 |
| 7TDY | X-ray | 1.53 Å | A=47-120 |
| 7TW8 | X-ray | 1.55 Å | A=47-123 |
| 8FRJ | X-ray | 1.57 Å | A=47-123 |
| 9DB5 | X-ray | 1.57 Å | A=47-121 |
| 8FT8 | X-ray | 1.6 Å | A=47-124 |
| 8FRK | X-ray | 1.61 Å | A=47-123 |
| 7TW7 | X-ray | 1.62 Å | A=47-123 |
| 8THA | X-ray | 1.68 Å | A=47-124 |
| 9ZNB | X-ray | 1.77 Å | A=47-124 |
| 7JU2 | X-ray | 1.85 Å | A/B=43-125 |
| 7T8J | X-ray | 1.89 Å | A=47-121 |
| 8FZU | X-ray | 1.9 Å | A/B/C=47-111 |
| 9ZVU | X-ray | 1.96 Å | A/B=47-122 |
| 9FEH | X-ray | 1.99 Å | A=47-123 |
| 9NGE | X-ray | 2.02 Å | A/B=47-122 |
Showing 20 of 43 experimental structures (best resolution first).
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