Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1) is a 468-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41586.
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The mean pLDDT of this model is 75.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:32004469, PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). Binds both PACAP27 and PACAP38 bioactive peptides (PubMed:32004469, PubMed:32047270, PubMed:35477937, PubMed:36385145). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32004469, PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). May regulate the release of adrenocorticotropin, luteinizing hormone,…
Interacts with maxadilan, a vasodilator peptide from Lutzomyia longipalpis saliva; the interaction results in ADCYAP1R1 activation (PubMed:32047270)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3N94 | X-ray | 1.8 Å | A=26-140 |
| 8E3X | EM | 2.3 Å | R=19-468 |
| 7JQD | X-ray | 2.7 Å | A=18-143 |
| 9P94 | EM | 3.0 Å | R=19-468 |
| 6P9Y | EM | 3.01 Å | R=19-468 |
| 9P93 | EM | 3.2 Å | R=19-468 |
| 6M1I | EM | 3.5 Å | A=23-438 |
| 6M1H | EM | 3.6 Å | A=23-438 |
| 9P92 | EM | 3.8 Å | R=19-468 |
| 6LPB | EM | 3.9 Å | R=21-417 |
| 2JOD | NMR | A=22-143 |
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