9ZBK: MTORC2
mTORC2 in complex with Akt1. Determined by electron microscopy at 2.6 Å resolution. Released 15 Apr 2026.
- Method
- Electron microscopy
- Resolution
- 2.6 Å
- Organism
- Homo sapiens
- Chains
- 5
- Atoms
- 30,622
- Mol. weight
- 574.42 kDa
- Ligands
- ZN, A1AID
- Released
- 15 Apr 2026
Explore 9ZBK in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9ZBK contains 232 α-helices and 63 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 135 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 82-92 | 11 | |
| α-helix | 121-134 | 14 | |
| α-helix | 142-156 | 15 | |
| α-helix | 162-178 | 17 | |
| α-helix | 187-195 | 9 | |
| α-helix | 203-219 | 17 | |
| α-helix | 232-245 | 14 | |
| α-helix | 254-256 | 3 | |
| α-helix | 257-275 | 19 | |
| α-helix | 278-292 | 15 | |
| α-helix | 361-380 | 20 | |
| α-helix | 386-401 | 16 | |
| α-helix | 407-410 | 4 | |
| α-helix | 413-425 | 13 | |
| α-helix | 430-443 | 14 | |
| α-helix | 447-450 | 4 | |
| α-helix | 452-462 | 11 | |
| α-helix | 481-493 | 13 | |
| α-helix | 495-509 | 15 | |
| α-helix | 515-527 | 13 | |
| α-helix | 529-546 | 18 | |
| α-helix | 579-591 | 13 | |
| α-helix | 600-609 | 10 | |
| α-helix | 616-628 | 13 | |
| α-helix | 649-665 | 17 | |
| α-helix | 669-677 | 9 | |
| α-helix | 681-683 | 3 | |
| α-helix | 684-687 | 4 | |
| α-helix | 690-700 | 11 | |
| α-helix | 705-718 | 14 | |
| α-helix | 719-721 | 3 | |
| α-helix | 723-743 | 21 | |
| α-helix | 747-763 | 17 | |
| α-helix | 765-768 | 4 | |
| α-helix | 769-771 | 3 | |
| α-helix | 772-783 | 12 | |
| α-helix | 793-809 | 17 | |
| α-helix | 811-813 | 3 | |
| α-helix | 817-829 | 13 | |
| α-helix | 834-851 | 18 | |
| α-helix | 856-860 | 5 | |
| α-helix | 864-874 | 11 | |
| α-helix | 878-891 | 14 | |
| α-helix | 896-904 | 9 | |
| α-helix | 929-936 | 8 | |
| α-helix | 943-960 | 18 | |
| α-helix | 965-967 | 3 | |
| α-helix | 968-982 | 15 | |
| α-helix | 987-989 | 3 | |
| α-helix | 990-1003 | 14 | |
| α-helix | 1009-1023 | 15 | |
| α-helix | 1024-1027 | 4 | |
| α-helix | 1028-1040 | 13 | |
| α-helix | 1048-1063 | 16 | |
| α-helix | 1064-1069 | 6 | |
| α-helix | 1071-1074 | 4 | |
| α-helix | 1075-1083 | 9 | |
| α-helix | 1088-1090 | 3 | |
| α-helix | 1091-1100 | 10 | |
| α-helix | 1104-1107 | 4 | |
| α-helix | 1111-1123 | 13 | |
| α-helix | 1129-1143 | 15 | |
| α-helix | 1153-1165 | 13 | |
| α-helix | 1170-1184 | 15 | |
| α-helix | 1185-1191 | 7 | |
| α-helix | 1192-1199 | 8 | |
| α-helix | 1207-1218 | 12 | |
| α-helix | 1229-1238 | 10 | |
| α-helix | 1263-1268 | 6 | |
| α-helix | 1277-1294 | 18 | |
| α-helix | 1298-1301 | 4 | |
| α-helix | 1304-1309 | 6 | |
| α-helix | 1311-1316 | 6 | |
| α-helix | 1318-1326 | 9 | |
| α-helix | 1331-1347 | 17 | |
| α-helix | 1351-1366 | 16 | |
| α-helix | 1380-1390 | 11 | |
| α-helix | 1393-1406 | 14 | |
| α-helix | 1410-1422 | 13 | |
| α-helix | 1426-1439 | 14 | |
| α-helix | 1447-1453 | 7 | |
| α-helix | 1456-1465 | 10 | |
| α-helix | 1474-1487 | 14 | |
| α-helix | 1490-1500 | 11 | |
| α-helix | 1506-1523 | 18 | |
| α-helix | 1527-1532 | 6 | |
| α-helix | 1541-1554 | 14 | |
| α-helix | 1558-1578 | 21 | |
| α-helix | 1583-1607 | 25 | |
| α-helix | 1613-1623 | 11 | |
| α-helix | 1630-1640 | 11 | |
| α-helix | 1646-1648 | 3 | |
| α-helix | 1650-1663 | 14 | |
| α-helix | 1666-1677 | 12 | |
| α-helix | 1681-1683 | 3 | |
| α-helix | 1688-1690 | 3 | |
| α-helix | 1694-1706 | 13 | |
| α-helix | 1711-1731 | 21 | |
| α-helix | 1741-1762 | 22 | |
| α-helix | 1769-1782 | 14 | |
| α-helix | 1787-1811 | 25 | |
| α-helix | 1871-1892 | 22 | |
| α-helix | 1900-1913 | 14 | |
| α-helix | 1917-1929 | 13 | |
| α-helix | 1933-1938 | 6 | |
| α-helix | 1939-1944 | 6 | |
| α-helix | 1951-1967 | 17 | |
| α-helix | 1969-1971 | 3 | |
| α-helix | 1973-1980 | 8 | |
| α-helix | 1985-2020 | 36 | |
| α-helix | 2023-2041 | 19 | |
| α-helix | 2045-2060 | 16 | |
| α-helix | 2065-2089 | 25 | |
| α-helix | 2094-2099 | 6 | |
| α-helix | 2102-2114 | 13 | |
| α-helix | 2115-2117 | 3 | |
| β-strand | 2120-2122 | 3 | 1 |
| α-helix | 2123-2126 | 4 | |
| α-helix | 2128-2132 | 5 | |
| β-strand | 2139 | 1 | 2 |
| α-helix | 2140 | 1 | |
| β-strand | 2152 | 1 | 2 |
| β-strand | 2153-2156 | 4 | 1 |
| β-strand | 2159-2162 | 4 | 1 |
| β-strand | 2170-2176 | 7 | 1 |
| β-strand | 2181-2188 | 8 | 1 |
| α-helix | 2194-2210 | 17 | |
| α-helix | 2213-2218 | 6 | |
| β-strand | 2227-2231 | 5 | 1 |
| β-strand | 2234-2238 | 5 | 1 |
| β-strand | 2244-2245 | 2 | 3 |
| α-helix | 2246-2257 | 12 | |
| α-helix | 2263-2271 | 9 | |
| α-helix | 2275-2277 | 3 | |
| α-helix | 2280-2292 | 13 | |
| α-helix | 2298-2305 | 8 | |
| α-helix | 2311-2334 | 24 | |
| α-helix | 2341-2343 | 3 | |
| β-strand | 2344-2346 | 3 | 3 |
| β-strand | 2353-2355 | 3 | 3 |
| α-helix | 2381-2385 | 5 | |
| α-helix | 2395-2409 | 15 | |
| α-helix | 2411-2422 | 12 | |
| α-helix | 2493-2509 | 17 | |
| α-helix | 2521-2532 | 12 | |
| α-helix | 2535-2538 | 4 | |
| α-helix | 2543-2545 | 3 | |
Chain B: 1 helix, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 13-19 | 7 | 4 |
| β-strand | 23-27 | 5 | 4 |
| β-strand | 34-39 | 6 | 4 |
| β-strand | 47-50 | 4 | 5 |
| β-strand | 56-60 | 5 | 5 |
| β-strand | 62 | 1 | 6 |
| β-strand | 65-69 | 5 | 5 |
| β-strand | 79-81 | 3 | 5 |
| β-strand | 87 | 1 | 6 |
| β-strand | 88-93 | 6 | 7 |
| β-strand | 99-104 | 6 | 7 |
| β-strand | 108-113 | 6 | 7 |
| β-strand | 123-126 | 4 | 7 |
| β-strand | 131-136 | 6 | 8 |
| β-strand | 142-147 | 6 | 8 |
| β-strand | 152-156 | 5 | 8 |
| β-strand | 162-165 | 4 | 8 |
| β-strand | 173-178 | 6 | 9 |
| β-strand | 184-189 | 6 | 9 |
| β-strand | 193-200 | 8 | 9 |
| α-helix | 206-208 | 3 | |
| β-strand | 209-217 | 9 | 9 |
| β-strand | 223-228 | 6 | 10 |
| β-strand | 234-239 | 6 | 10 |
| β-strand | 243-248 | 6 | 10 |
| β-strand | 254-259 | 6 | 10 |
| β-strand | 273-278 | 6 | 11 |
| β-strand | 284-289 | 6 | 11 |
| β-strand | 293-298 | 6 | 11 |
| β-strand | 304-309 | 6 | 11 |
| β-strand | 315-322 | 8 | 4 |
Chain C: 76 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 34-46 | 13 | |
| α-helix | 53-70 | 18 | |
| α-helix | 74-77 | 4 | |
| α-helix | 81-91 | 11 | |
| α-helix | 97-110 | 14 | |
| α-helix | 114-122 | 9 | |
| α-helix | 126-134 | 9 | |
| α-helix | 140-156 | 17 | |
| α-helix | 164-175 | 12 | |
| α-helix | 184-197 | 14 | |
| α-helix | 199-205 | 7 | |
| α-helix | 208-216 | 9 | |
| α-helix | 221-236 | 16 | |
| α-helix | 238-243 | 6 | |
| α-helix | 250-254 | 5 | |
| α-helix | 255-258 | 4 | |
| α-helix | 273-291 | 19 | |
| α-helix | 295-301 | 7 | |
| α-helix | 308-316 | 9 | |
| α-helix | 321-335 | 15 | |
| α-helix | 346-351 | 6 | |
| α-helix | 360-362 | 3 | |
| α-helix | 368-376 | 9 | |
| α-helix | 378-379 | 2 | |
| β-strand | 386 | 1 | 12 |
| α-helix | 387-401 | 15 | |
| α-helix | 404-413 | 10 | |
| α-helix | 417-437 | 21 | |
| α-helix | 440-443 | 4 | |
| α-helix | 450-456 | 7 | |
| α-helix | 463-485 | 23 | |
| α-helix | 492-504 | 13 | |
| α-helix | 512-520 | 9 | |
| α-helix | 525-534 | 10 | |
| α-helix | 548-556 | 9 | |
| α-helix | 568-581 | 14 | |
| β-strand | 592 | 1 | 13 |
| α-helix | 598-613 | 16 | |
| α-helix | 617-636 | 20 | |
| α-helix | 649-653 | 5 | |
| β-strand | 654 | 1 | 13 |
| α-helix | 656-658 | 3 | |
| α-helix | 659-667 | 9 | |
| α-helix | 670-679 | 10 | |
| α-helix | 682-688 | 7 | |
| α-helix | 696-704 | 9 | |
| α-helix | 712-722 | 11 | |
| α-helix | 726-741 | 16 | |
| α-helix | 751-758 | 8 | |
| α-helix | 764-777 | 14 | |
| α-helix | 781-790 | 10 | |
| α-helix | 799-806 | 8 | |
| α-helix | 807-810 | 4 | |
| α-helix | 812-819 | 8 | |
| α-helix | 823-830 | 8 | |
| α-helix | 831-835 | 5 | |
| α-helix | 836-851 | 16 | |
| β-strand | 877 | 1 | 12 |
| α-helix | 882-886 | 5 | |
| α-helix | 890-898 | 9 | |
| α-helix | 902-910 | 9 | |
| α-helix | 919-933 | 15 | |
| α-helix | 937-944 | 8 | |
| α-helix | 949-958 | 10 | |
| α-helix | 962-975 | 14 | |
| α-helix | 979-986 | 8 | |
| β-strand | 990-992 | 3 | 14 |
| α-helix | 1008-1011 | 4 | |
| α-helix | 1013-1016 | 4 | |
| β-strand | 1428-1430 | 3 | 14 |
| α-helix | 1433-1435 | 3 | |
| α-helix | 1445-1447 | 3 | |
| α-helix | 1480-1486 | 7 | |
| α-helix | 1494-1496 | 3 | |
| α-helix | 1524-1529 | 6 | |
| α-helix | 1531-1537 | 7 | |
| α-helix | 1608-1624 | 17 | |
| α-helix | 1629-1642 | 14 | |
| α-helix | 1644-1647 | 4 | |
| α-helix | 1650-1661 | 12 | |
| α-helix | 1667-1675 | 9 | |
| α-helix | 1683-1693 | 11 | |
Chain D: 10 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-20 | 14 | |
| α-helix | 26-30 | 5 | |
| α-helix | 85-91 | 7 | |
| α-helix | 94-98 | 5 | |
| β-strand | 104-106 | 3 | 5 |
| α-helix | 118-121 | 4 | |
| α-helix | 142-145 | 4 | |
| α-helix | 159-162 | 4 | |
| β-strand | 174-180 | 7 | 15 |
| β-strand | 194-198 | 5 | 15 |
| α-helix | 203-216 | 14 | |
| α-helix | 222-224 | 3 | |
| α-helix | 227-229 | 3 | |
| β-strand | 231-235 | 5 | 15 |
| β-strand | 241-242 | 2 | 15 |
| β-strand | 261-265 | 5 | 15 |
Chain E: 10 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 152-158 | 7 | 16 |
| β-strand | 163-168 | 6 | 16 |
| β-strand | 175-181 | 7 | 16 |
| α-helix | 183-188 | 6 | |
| α-helix | 192-204 | 13 | |
| β-strand | 207 | 1 | 17 |
| β-strand | 210 | 1 | 17 |
| β-strand | 215-218 | 4 | 16 |
| β-strand | 223-228 | 6 | 16 |
| β-strand | 234 | 1 | 18 |
| α-helix | 235-242 | 8 | |
| α-helix | 247-265 | 19 | |
| β-strand | 281 | 1 | 18 |
| α-helix | 318-321 | 4 | |
| α-helix | 328-344 | 17 | |
| α-helix | 354-363 | 10 | |
| α-helix | 374-383 | 10 | |
| α-helix | 399-403 | 5 | |
| α-helix | 415-418 | 4 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Serine/threonine-protein kinase mTOR | A | protein | 2470 | Homo sapiens | P42345 (AlphaFold model) |
| Target of rapamycin complex subunit LST8 | B | protein | 318 | Homo sapiens | Q9BVC4 (AlphaFold model) |
| Rapamycin-insensitive companion of mTOR | C | protein | 1670 | Homo sapiens | Q6R327 (AlphaFold model) |
| Target of rapamycin complex 2 subunit MAPKAP1 | D | protein | 269 | Homo sapiens | Q9BPZ7 (AlphaFold model) |
| RAC-alpha serine/threonine-protein kinase | E | protein | 338 | Homo sapiens | P31749 |
Sequence of entity 1 (A), FASTA
>9ZBK_1 Serine/threonine-protein kinase mTOR (chains A)
ANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDT
FTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVW
DPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDD
RIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSF
QAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLK
CRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGL
LSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQ
DIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPK
GLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIR
MEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASL
DERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILT
ELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVL
ATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYR
KYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSE
SKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIF
KSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMR
EFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAA
IQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPI
VRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKG
YTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDD
WLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIR
SIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHY
KELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDA
LVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAA
AWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMA
GESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMV
RSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYA
YMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQL
NLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRH
ASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLM
YTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVI
PQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMC
EHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMME
RGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLT
SLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNG
HEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGW
VPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDL
AKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFG
DCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLE
AFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESI
HSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLC
QCYIGWCPFW
Sequence of entity 2 (B), FASTA
>9ZBK_2 Target of rapamycin complex subunit LST8 (chains B)
TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIR
MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ
VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA
AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI
WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKR
EYGGHQKAVVCLAFNDSV
Sequence of entity 3 (C), FASTA
>9ZBK_3 Rapamycin-insensitive companion of mTOR (chains C)
NVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYEDI
IICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERT
QALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVAL
RGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRH
SPDTAEGQLKEDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIR
RGLLEVLYDIFRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSR
PDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSH
HLHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIAT
HQKRDQYLRVQKDIFILKDTEEALLINLRDSQVLQHKENLEWNWNLIGTILKWPNVNLRN
YKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLE
DLVKDIVQWLNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQC
LLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANV
EFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLL
LLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEALTTYRKPVDGDNYV
RRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQNIITELCRNVRTPDLDKWEEIKKLK
ASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDI
LKCHNWDAVRHSRKHLWPVVPDDVEQLCNELSSIPSTLSLNSESTSSRHNSESESVPSSM
FILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGPIKDKNSFPFFASSKLVKNRILNSLTL
PNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQLETSFM
GNKHIEDTGSTPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQSFNTDT
TTSGISSMSSSPSRETVGVDATTMDTDCGSMSTVVSTKTIKTSHYLTPQSNHLSLSKSNS
VSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPS
LSHSEALASPAKDVLFTDTITMKANSFESRLTPSRFMKALSYASLDKEDLLSPINQNTLQ
RSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQVKDIPYFQTKNIPPHDDRGARAFAHD
AGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDASLFLESTEDTGLQEHTDDNCLYCV
CIEILGFQPSNQLSAICSHSDFQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGVSQEG
SASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLVINLSSSVSTKCHETGLLTIKEKYP
QTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDVQFLQMHEEAEAVLA
Sequence of entity 4 (D), FASTA
>9ZBK_4 Target of rapamycin complex 2 subunit MAPKAP1 (chains D)
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITTSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPSSGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKKY
Sequence of entity 5 (E), FASTA
>9ZBK_5 RAC-alpha serine/threonine-protein kinase (chains E)
PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR
VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA
LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV
LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL
SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE
EFTAQMITITPPDQDDSMECVDSERRPHFPQFCYSASG
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 1 |
| A1AID | (1M,9M)-1-{4-[4-(prop-2-enoyl)piperazin-1-yl]-3-(trifluoromethyl)phenyl}-9-(qui… | C35 H26 F3 N5 O2 | 1 |
Primary citation
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2. Taylor, M.S., Chen, M., Hancock, M. et al. Science (2026) 391:eadv7111-eadv7111. DOI 10.1126/science.adv7111 · PubMed
Other PDB entries of the same protein (UniProt P42345 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4DRI 1.45 Å, Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of…
- 9DBO 1.55 Å, Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR
- 5GPG 1.67 Å, Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB…
- 5WBH 1.75 Å, Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
- 4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
- 3FAP 1.85 Å, Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb…
- 8PPZ 1.85 Å, Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
- 8XI9 1.85 Å, Crystal structure of FRB-FKBP fusion protein in complex with rapamycin
- 9PIW 1.9 Å, Crystal structure of a synthetic Fab (1A) in complex with the FRB domain of mTOR
- 9DL0 2.0 Å, Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR
- 9PJ1 2.05 Å, Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of…
- 9PIU 2.18 Å, Crystal structure of a synthetic Fab (2C) in complex with the FRB domain of mTOR
Browse structure collections
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