Epidermal growth factor receptor substrate 15 (EPS15) is a 896-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P42566.
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The mean pLDDT of this model is 66.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 26% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2
Interacts with SGIP1 (PubMed:26822536). Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM or STAM2. Binds AP2A2. Interacts with AP2B1; clathrin competes with EPS15. Binds STON2. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP.…
Cytoplasm, Cell membrane, Membrane, clathrin-coated pit, Early endosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4RHG | X-ray | 1.58 Å | B=846-854 |
| 4RH5 | X-ray | 1.6 Å | B=846-854 |
| 4RH9 | X-ray | 1.6 Å | B=846-854 |
| 4S0G | X-ray | 1.72 Å | B=846-854 |
| 2IV9 | X-ray | 1.9 Å | P=719-730 |
| 5JP2 | X-ray | 2.4 Å | E/F=615-637 |
| 5AWT | X-ray | 2.7 Å | B=640-649 |
| 5AWU | X-ray | 2.7 Å | B=645-654 |
| 1C07 | NMR | A=217-311 | |
| 1EH2 | NMR | A=121-219 | |
| 1F8H | NMR | A=121-215 | |
| 1FF1 | NMR | A=121-215 | |
| 2JXC | NMR | A=121-215 |
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