Tyrosine-protein kinase ZAP-70 (ZAP70) is a 619-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P43403.
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The mean pLDDT of this model is 84.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the phosphorylated TCR components CD3E and CD247/CD3Z through ITAM motif at the plasma membrane (PubMed:7509083). This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by…
Interacts with CD247/CD3Z; this interaction docks ZAP70 at the stimulated TCR (PubMed:1423621, PubMed:26783323, PubMed:7659156). Interacts with NFAM1 (PubMed:15143214). Interacts with adapter protein SLA; this interaction negatively regulates T-cell receptor signaling (PubMed:10449770). Interacts with FCRL3 (PubMed:12051764, PubMed:19843936). Interacts with VAV1 (PubMed:9151714). Interacts with…
Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7SIY | X-ray | 1.48 Å | Z=292-296 |
| 2OQ1 | X-ray | 1.9 Å | A=3-256 |
| 2Y1N | X-ray | 2.0 Å | B/D=286-297 |
| 4XZ0 | X-ray | 2.0 Å | A=1-259 |
| 2CBL | X-ray | 2.1 Å | B=286-297 |
| 3ZNI | X-ray | 2.21 Å | B/F/J/N=286-297 |
| 1U59 | X-ray | 2.3 Å | A=327-606 |
| 5O76 | X-ray | 2.47 Å | B/D=286-297 |
| 1M61 | X-ray | 2.5 Å | A=1-256 |
| 2OZO | X-ray | 2.6 Å | A=1-606 |
| 4A4C | X-ray | 2.7 Å | B=286-297 |
| 4A4B | X-ray | 2.79 Å | B=286-297 |
| 4XZ1 | X-ray | 2.8 Å | A=1-259 |
| 1FBV | X-ray | 2.9 Å | B=289-297 |
| 4K2R | X-ray | 3.0 Å | A=1-606 |
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