Interleukin-12 subunit beta (Il12b) is a 335-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P43432.
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The mean pLDDT of this model is 87.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC
Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (PubMed:34374750)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8CR5 | X-ray | 2.15 Å | A=1-335 |
| 6SFF | X-ray | 2.4 Å | A=1-335 |
| 8CR6 | X-ray | 2.85 Å | A=1-335 |
| 6SP3 | X-ray | 3.0 Å | A/B=1-335 |
| 7R3N | X-ray | 3.16 Å | A/B/C/D=1-335 |
| 6SMC | X-ray | 3.5 Å | A/B/C/D=1-335 |
| 8PB1 | EM | 3.5 Å | B=23-335 |
| 8ODZ | EM | 3.6 Å | B=23-335 |
| 7PUR | X-ray | 3.9 Å | A/B=1-335 |
| 8OE0 | EM | 4.6 Å | B=23-335 |
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