Histone transcription regulator 3 (HIR3) is a 1648-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P47171.
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The mean pLDDT of this model is 77.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 61% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
HIR1, HIR2 and HIR3 are repressors of histone gene transcription. They are required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. Also has a role in nucleosome assembly
Component of the HIR complex, composed of HIR1, HIR2, HIR3 and HPC2 (PubMed:16264190, PubMed:16303565). This complex may consist of one copy of HIR1 and HIR3 and two copies of HIR2 and HPC2 (PubMed:16264190). The HIR complex interacts with ASF1 (PubMed:16303565). Interacts with RTT106 (PubMed:19683497)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8GHL | EM | 2.96 Å | D/J=1-1648 |
| 8GHN | EM | 2.96 Å | D/J=1-1648 |
| 8GHA | EM | 6.8 Å | D=1-1648 |
| 8GHM | EM | 12.0 Å | D/J=1-1648 |
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